Mouse Anti-KCNJ4 Recombinant Antibody (10F748) (CBMAB-K0581-LY)

Name: Mouse Anti-KCNJ4 Recombinant Antibody (10F748)
SKU: CBMAB-K0581-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

10F748

Application

IHC, WB

Immunogen

Fusion protein corresponding to aa390-445 of Kir2.3

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium inwardly rectifying channel subfamily J member 4

Introduction

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	3761
Mouse	16520
Rat	116649

UniProt ID

Human	P48050
Mouse	P52189
Rat	P52190

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

Biological Process

Potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane; Cell junction, synapse, postsynaptic cell membrane; Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.

Topology

Cytoplasmic: 1-55
Helical: 56-80
Extracellular: 81-120
Helical: 121-132
Pore-forming: 133-139
Extracellular: 140-148
Helical: 149-170
Cytoplasmic: 171-445

Song, R., Chen, H., Zhan, R., Han, M., Zhao, L., & Shen, X. (2023). Vitamin E protects dopaminergic neurons against manganese-induced neurotoxicity through stimulation of CHRM1 and KCNJ4. Journal of Trace Elements in Medicine and Biology, 127326.

Wu, X. Y., Xie, Y., Zhou, L. Y., Zhao, Y. Y., Zhang, J., Zhang, X. F., ... & Yu, X. Y. (2021). Long noncoding RNA POU6F2-AS1 regulates lung cancer aggressiveness through sponging miR-34c-5p to modulate KCNJ4 expression. Genetics and molecular biology, 44.

Wu, X. Y., & Yu, X. Y. (2019). Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma. Journal of Biochemical and Molecular Toxicology, 33(4), e22270.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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