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Mouse Anti-KCNJ4 Recombinant Antibody (S124B-38) (CBMAB-K0583-LY)

This product is antibody recognizes KCNJ4. The antibody S124B-38 immunoassay techniques such as: IF, IHC-P, WB.
See all KCNJ4 antibodies

Summary

Host Animal
Mouse
Specificity
Rat, Human, Mouse
Clone
S124B-38
Antibody Isotype
IgG1
Application
IF, IHC-P, WB

Basic Information

Immunogen
Fusion protein amino acids 362-427 of rat Kir2. 2
Specificity
Rat, Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium inwardly rectifying channel subfamily J member 4
Introduction
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3761
Mouse16520
Rat116649
UniProt ID
HumanP48050
MouseP52189
RatP52190
Alternative Names
Hirk2
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
Biological Process
Potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Regulation of ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane; Cell junction, synapse, postsynaptic cell membrane; Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization.
Topology
Cytoplasmic: 1-55
Helical: 56-80
Extracellular: 81-120
Helical: 121-132
Pore-forming: 133-139
Extracellular: 140-148
Helical: 149-170
Cytoplasmic: 171-445
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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