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Mouse Anti-KCNMB3 Recombinant Antibody (2C12) (CBMAB-K0594-LY)

This product is antibody recognizes KCNMB3. The antibody 2C12 immunoassay techniques such as: ELISA, WB.
See all KCNMB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C12
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
KCNMB3 (82 a.a. ~ 181 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: FMLSIQREES TCTAIHTDIM DDWLDCAFTC GVHCHGQGKY PCLQVFVNLS HPGQKALLHY NEEAVQINPK CFYTPKCHQD RNDLLNSALD IKEFFDHKNG
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3
Introduction
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]
Entrez Gene ID
27094
UniProt ID
Q9NPA1
Alternative Names
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3; Potassium Large Conductance Calcium-Activated Channel; Subfamily M Beta Member 3; Calcium-Activated Potassium Channel; Subfamily M Subunit Beta-3; Potassium Channel Subfamily M Regulatory Beta Subunit 3; Charybdotoxin Receptor Subunit Beta-3; Big Potassium Channel Beta Subunit 3; Maxi K Channel Subunit Beta-3; MaxiK Channel Beta-Subunit 3; BK Channel Beta Subunit 3; BK Channel Subunit Beta-3; K(VCA)BETA-3;
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Biological Process
Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-60
Helical: 61-81
Extracellular: 82-207
Helical: 208-228
Cytoplasmic: 229-279
PTM
N-glycosylated.
The extracellular domain contains disulfide bond essential for the gating mechanism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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