Mouse Anti-Kcnmb3 Recombinant Antibody (CBYC-P092) (CBMAB-P0420-YC)

Name: Mouse Anti-Kcnmb3 Recombinant Antibody (CBYC-P092)
SKU: CBMAB-P0420-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-P092

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3

Introduction

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. A related pseudogene has been identified on chromosome 22.

Entrez Gene ID

27094

UniProt ID

Q9NPA1

Alternative Names

BKBETA3; SLOBETA3; KCNMB2; KCNMBL; HBETA3

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.

Biological Process

Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-60
Helical: 61-81
Extracellular: 82-207
Helical: 208-228
Cytoplasmic: 229-279

PTM

N-glycosylated.
The extracellular domain contains disulfide bond essential for the gating mechanism.

Imari, K., Harada, Y., Zhang, J., Mori, Y., & Hayashi, Y. (2019). KCNMB3 in spinal microglia contributes to the generation and maintenance of neuropathic pain in mice. International Journal of Molecular Medicine, 44(4), 1585-1593.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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