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Mouse Anti-Kcnmb3 Recombinant Antibody (CBYC-P092) (CBMAB-P0420-YC)

Provided herein is a Mouse monoclonal antibody against Human Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all Kcnmb3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P092
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3
Introduction
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. A related pseudogene has been identified on chromosome 22.
Entrez Gene ID
27094
UniProt ID
Q9NPA1
Alternative Names
BKBETA3; SLOBETA3; KCNMB2; KCNMBL; HBETA3
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Biological Process
Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-60
Helical: 61-81
Extracellular: 82-207
Helical: 208-228
Cytoplasmic: 229-279
PTM
N-glycosylated.
The extracellular domain contains disulfide bond essential for the gating mechanism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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