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Mouse Anti-KCNMB4 Recombinant Antibody (1G7) (CBMAB-K0600-LY)

This product is antibody recognizes KCNMB4. The antibody 1G7 immunoassay techniques such as: ELISA.
See all KCNMB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G7
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
KCNMB4 (1 a.a. ~ 211 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4
Introduction
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4; Potassium Large Conductance Calcium-Activated Channel; Subfamily M; Beta Member 4; Calcium-Activated Potassium Channel; Subfamily M Subunit Beta-4; Potassium Channel Subfamily M Regulatory Beta Subunit 4; Charybdotoxin Receptor Subunit Beta-4; Big Potassium Channel Beta Subunit 4; Maxi K Channel Subunit Beta-4; MaxiK Channel Beta-Subunit 4; BK Channel Beta Subunit 4;
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
Biological Process
Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of vasoconstrictionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Membrane
Topology
Cytoplasmic: 1-19
Helical: 20-40
Extracellular: 41-167
Helical: 168-188
Cytoplasmic: 189-210
PTM
Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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