Mouse Anti-KCNMB4 Recombinant Antibody (CBLY1-055) (CBMAB-K0598-LY)

Name: Mouse Anti-KCNMB4 Recombinant Antibody (CBLY1-055)
SKU: CBMAB-K0598-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLY1-055

Application

WB, IP, IF, ELISA

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4

Introduction

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

Entrez Gene ID

27345

UniProt ID

Q86W47

Alternative Names

Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4; Potassium Large Conductance Calcium-Activated Channel; Subfamily M; Beta Member 4; Calcium-Activated Potassium Channel; Subfamily M Subunit Beta-4; Potassium Channel Subfamily M Regulatory Beta Subunit 4; Charybdotoxin Receptor Subunit Beta-4; Big Potassium Channel Beta Subunit 4; Maxi K Channel Subunit Beta-4; MaxiK Channel Beta-Subunit 4; BK Channel Beta Subunit 4;

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.

Biological Process

Action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Detection of calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Neuronal action potentialManual Assertion Based On ExperimentIDA:UniProtKB
Potassium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of neurotransmitter secretionManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of vasoconstrictionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Membrane

Topology

Cytoplasmic: 1-19
Helical: 20-40
Extracellular: 41-167
Helical: 168-188
Cytoplasmic: 189-210

PTM

Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics.
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin.

Iwanicki, T., Balcerzyk, A., Kazek, B., Emich-Widera, E., Likus, W., Iwanicka, J., ... & Niemiec, P. (2022). Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population. Journal of Autism and Developmental Disorders, 1-6.

Feng, Y., Liu, Y., Cao, P. X., Sun, X., Li, K. X., Li, X. Y., ... & Li, B. Y. (2020). Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1. 1 β4-subunit Expression. Neuroscience, 442, 168-182.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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