Mouse Anti-KCNN4 Recombinant Antibody (CBT2056) (V2LY-0625-LY1753)

Name: Mouse Anti-KCNN4 Recombinant Antibody (CBT2056)
SKU: V2LY-0625-LY1753
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-KCNN4 Recombinant Antibody (CBT2056) (V2LY-0625-LY1753) in ELISA

Mouse Anti-KCNN4 Recombinant Antibody (CBT2056) (V2LY-0625-LY1753) in WB

Mouse Anti-KCNN4 Recombinant Antibody (CBT2056) (V2LY-0625-LY1753) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT2056

Application

WB, FC

Immunogen

Purified recombinant fragment of human KCNN4 (AA: extra 286-427) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium calcium-activated channel subfamily N member 4

Entrez Gene ID

3783

UniProt ID

O15554

Function

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990).
Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614).
Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).

Biological Process

Calcium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cell volume homeostasisIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Immune system processIEA:UniProtKB-KW
Ion transportManual Assertion Based On ExperimentIBA:GO_Central
Phospholipid translocationIEA:Ensembl
Positive regulation of potassium ion transmembrane transportTAS:Reactome
Positive regulation of protein secretionIEA:Ensembl
Positive regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Saliva secretionIEA:Ensembl
Stabilization of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cell membrane

Involvement in disease

Dehydrated hereditary stomatocytosis 2 (DHS2):
An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur.

PTM

Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.

Fan, J., Tian, R., Yang, X., Wang, H., Shi, Y., Fan, X., ... & Li, L. (2022). KCNN4 promotes the stemness potentials of liver cancer stem cells by enhancing glucose metabolism. International journal of molecular sciences, 23(13), 6958.

Mo, X., Zhang, C. F., Xu, P., Ding, M., Ma, Z. J., Sun, Q., ... & Xia, H. P. (2022). KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma. Acta Pharmacologica Sinica, 43(3), 735-746.

Chen, S., Su, X., & Mo, Z. (2022). Kcnn4 is a potential biomarker for predicting cancer prognosis and an essential molecule that remodels various components in the tumor microenvironment: A pan-cancer study. Frontiers in Molecular Biosciences, 9, 812815.

Xu, P., Mo, X., Xia, R., Jiang, L., Zhang, C., Xu, H., ... & Xia, H. (2021). KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways. Cancer Biomarkers, 31(2), 187-201.

Chen, S., Wang, C., Su, X., Dai, X., Li, S., & Mo, Z. (2021). KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma. Translational andrology and urology, 10(6), 2454.

Li, Q. T., Feng, Y. M., Ke, Z. H., Qiu, M. J., He, X. X., Wang, M. M., ... & Xiong, Z. F. (2020). KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma. Journal of Investigative Medicine, 68(1), 68-74.

Wen, J., Lin, B., Lin, L., Chen, Y., & Wang, O. (2020). KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression. Aging (Albany NY), 12(16), 16437.

Lin, P., Li, J., Ye, F., Fu, W., Hu, X., Shao, Z., & Song, C. (2020). KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. American journal of cancer research, 10(10), 3302.

Süss, C., Broncy, L., Pollinger, K., Kunst, C., Gülow, K., Müller, M., & Wölfel, G. (2020). KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels. Journal of Gastrointestinal & Liver Diseases, 29(4).

Hynes, D., & Harvey, B. J. (2019). Dexamethasone reduces airway epithelial Cl− secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K+ channels. Steroids, 151, 108459.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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