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Mouse Anti-KCNN4 Recombinant Antibody (CF254) (CBMAB-FT235LY)

The product is antibody recognizes KCNN4 . The antibody CF254 immunoassay techniques such as: ELISA, WB.
See all KCNN4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CF254
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
potassium calcium-activated channel subfamily N member 4
Introduction
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human3783
Mouse16534
Rat65206
UniProt ID
HumanO15554
MouseO89109
RatQ9QYW1
Alternative Names
IK1, IKCA1, KCA4, SK4
Function
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990).
Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614).
Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580).
Biological Process
Calcium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cell volume homeostasisIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:ProtInc
Immune system processIEA:UniProtKB-KW
Ion transportManual Assertion Based On ExperimentIBA:GO_Central
Phospholipid translocationIEA:Ensembl
Positive regulation of potassium ion transmembrane transportTAS:Reactome
Positive regulation of protein secretionIEA:Ensembl
Positive regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Saliva secretionIEA:Ensembl
Stabilization of membrane potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Dehydrated hereditary stomatocytosis 2 (DHS2):
An autosomal dominant hemolytic anemia characterized by primary erythrocyte dehydration. Erythrocytes exhibit decreased total cation and potassium content that are not accompanied by a proportional net gain of sodium and water. Affected individuals typically manifest mild to moderate compensated hemolytic anemia, with an increased erythrocyte mean corpuscular hemoglobin concentration and a decreased osmotic fragility, both of which reflect cellular dehydration. Their red cells exhibit a panel of various shape abnormalities such as elliptocytes, hemighosts, schizocytes, and very rare stomatocytic cells. Complications such as splenomegaly and cholelithiasis, resulting from increased red cell trapping in the spleen and elevated bilirubin levels, respectively, may occur.
PTM
Phosphorylation at His-358 by NDKB activates the channel, and conversely it's dephosphorylation by PHPT1 inhibits the channel.

Fan, J., Tian, R., Yang, X., Wang, H., Shi, Y., Fan, X., ... & Li, L. (2022). KCNN4 promotes the stemness potentials of liver cancer stem cells by enhancing glucose metabolism. International journal of molecular sciences, 23(13), 6958.

Mo, X., Zhang, C. F., Xu, P., Ding, M., Ma, Z. J., Sun, Q., ... & Xia, H. P. (2022). KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma. Acta Pharmacologica Sinica, 43(3), 735-746.

Chen, S., Su, X., & Mo, Z. (2022). Kcnn4 is a potential biomarker for predicting cancer prognosis and an essential molecule that remodels various components in the tumor microenvironment: A pan-cancer study. Frontiers in Molecular Biosciences, 9, 812815.

Xu, P., Mo, X., Xia, R., Jiang, L., Zhang, C., Xu, H., ... & Xia, H. (2021). KCNN4 promotes the progression of lung adenocarcinoma by activating the AKT and ERK signaling pathways. Cancer Biomarkers, 31(2), 187-201.

Chen, S., Wang, C., Su, X., Dai, X., Li, S., & Mo, Z. (2021). KCNN4 is a potential prognostic marker and critical factor affecting the immune status of the tumor microenvironment in kidney renal clear cell carcinoma. Translational andrology and urology, 10(6), 2454.

Li, Q. T., Feng, Y. M., Ke, Z. H., Qiu, M. J., He, X. X., Wang, M. M., ... & Xiong, Z. F. (2020). KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma. Journal of Investigative Medicine, 68(1), 68-74.

Wen, J., Lin, B., Lin, L., Chen, Y., & Wang, O. (2020). KCNN4 is a diagnostic and prognostic biomarker that promotes papillary thyroid cancer progression. Aging (Albany NY), 12(16), 16437.

Lin, P., Li, J., Ye, F., Fu, W., Hu, X., Shao, Z., & Song, C. (2020). KCNN4 induces multiple chemoresistance in breast cancer by regulating BCL2A1. American journal of cancer research, 10(10), 3302.

Süss, C., Broncy, L., Pollinger, K., Kunst, C., Gülow, K., Müller, M., & Wölfel, G. (2020). KCNN4 Expression Is Elevated in Inflammatory Bowel Disease: This Might Be a Novel Marker and Therapeutic Option Targeting Potassium Channels. Journal of Gastrointestinal & Liver Diseases, 29(4).

Hynes, D., & Harvey, B. J. (2019). Dexamethasone reduces airway epithelial Cl− secretion by rapid non-genomic inhibition of KCNQ1, KCNN4 and KATP K+ channels. Steroids, 151, 108459.

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For research use only. Not intended for any clinical use.

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