Mouse Anti-KDELR1 Recombinant Antibody (KR-10) (CBMAB-K0068-LY)

Name: Mouse Anti-KDELR1 Recombinant Antibody (KR-10)
SKU: CBMAB-K0068-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

KR-10

Application

WB, IHC-P, IF/ICC, IP

Immunogen

A 21 residue synthetic peptide based on the bovine KDEL receptor and the peptide coupled to KLH

Specificity

Cattle, Human, Mouse, Rat, Rabbit, Chicken, Monkey, Pig, Sheep, Hamster, Frog

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% Glycerol

Preservative

0.09% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

KDEL Endoplasmic Reticulum Protein Retention Receptor 1

Introduction

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	10945
Mouse	68137
Rat	361577
Cattle	618184
Rabbit	100349892
Monkey	717928
Pig	100520962
Sheep	101122047
Hamster	100750912
Frog	395012

UniProt ID

Human	P24390
Mouse	Q99JH8
Rat	Q569A6
Cattle	P33946
Monkey	A0A0D9S2T7
Pig	F2Z4Z3
Sheep	W5PQ26
Hamster	A0A2Z5WAD6
Frog	Q5XHA2

Function

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Protein retention in ER lumenManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
T cell apoptotic processIEA:Ensembl
T cell differentiationIEA:Ensembl

Cellular Location

Golgi apparatus membrane; Cytoplasmic vesicle, COPI-coated vesicle membrane; Endoplasmic reticulum membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane. Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.

Topology

Lumenal: 1-4
Helical: 5-24
Cytoplasmic: 25-32
Helical: 33-52
Lumenal: 53-58
Helical: 59-79
Cytoplasmic: 80-92
Helical: 93-110
Lumenal: 111-116
Helical: 117-135
Cytoplasmic: 136-149
Helical: 150-168
Lumenal: 169-178
Helical: 179-199
Cytoplasmic: 200-212

PTM

Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.

Yuan, Y., Yang, B., Qi, Z., Han, Z., Cai, J., & Song, J. (2022). KDELR1 Is an Independent Prognostic Predictor and Correlates With Immunity in Glioma. Frontiers in Oncology, 12, 783721.

Blum, A., Khalifa, S., Nordström, K., Simon, M., Schulz, M. H., & Schmitt, M. J. (2019). Transcriptomics of a KDELR1 knockout cell line reveals modulated cell adhesion properties. Scientific Reports, 9(1), 10611.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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