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KDELR1

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. [provided by RefSeq, Jul 2008]

Full Name

KDEL Endoplasmic Reticulum Protein Retention Receptor 1

Function

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum.

Biological Process

Endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Protein retention in ER lumenManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulumManual Assertion Based On ExperimentIDA:UniProtKB
T cell apoptotic processIEA:Ensembl
T cell differentiationIEA:Ensembl

Cellular Location

Golgi apparatus membrane; Cytoplasmic vesicle, COPI-coated vesicle membrane; Endoplasmic reticulum membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane. Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.

Topology

Lumenal: 1-4
Helical: 5-24
Cytoplasmic: 25-32
Helical: 33-52
Lumenal: 53-58
Helical: 59-79
Cytoplasmic: 80-92
Helical: 93-110
Lumenal: 111-116
Helical: 117-135
Cytoplasmic: 136-149
Helical: 150-168
Lumenal: 169-178
Helical: 179-199
Cytoplasmic: 200-212

PTM

Phosphorylation by PKA at Ser-209 is required for endoplasmic reticulum retention function.

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Anti-KDELR1 antibodies

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Mouse Anti-KDELR1 Recombinant Antibody (KD10-2) (CBMAB-K0653-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Monkey

Clone: KD10-2

Application*: WB, IF/IC

Mouse Anti-KDELR1 Recombinant Antibody (2E7) (CBMAB-K0651-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Common fruit fly, Plant, Wheat

Clone: 2E7

Application*: WB, P, IC/IF

Mouse Anti-KDELR1 Recombinant Antibody (2-00E-007) (CBMAB-K0650-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Yeast, Common fruit fly, Plant

Clone: 2-00E-007

Application*: IF, WB

Mouse Anti-KDELR1 Recombinant Antibody (10C3) (CBMAB-K0647-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Mouse, Rat, Human, Bird

Clone: 10C3

Application*: IP, P, IC, F, EM, IC/IF

Mouse Anti-KDELR1 Recombinant Antibody (9L799) (CBMAB-K0652-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Chicken, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Frog

Clone: 9L799

Application*: F, IC, IH, IP, WB

Mouse Anti-KDELR1 Recombinant Antibody (1D5) (CBMAB-K0649-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 1D5

Application*: IC, WB

Mouse Anti-KDELR1 Recombinant Antibody (10F745) (CBMAB-K0648-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 10F745

Application*: IF, WB

Mouse Anti-KDELR1 Recombinant Antibody (KR-10) (CBMAB-K0068-LY)

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Target: KDELR1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Mouse, Rat, Rabbit, Chicken, Monkey, Pig, Sheep, Hamster, Frog

Clone: KR-10

Application*: WB, P, IF/IC, IP

Rabbit Anti-KDELR1 Recombinant Antibody (CBLY1-005) (CBMAB-K0067-LY)

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Target: KDELR1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLY1-005

Application*: F, IC/IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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