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Rabbit Anti-KDM3B Recombinant Antibody (C6D12) (CBMAB-0304-WJ)

This product is a rabbit antibody that recognizes KDM3B. The antibody C6D12 can be used for immunoassay techniques such as: WB, IP, IHC-P.
See all KDM3B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
C6D12
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lysine Demethylase 3B
Introduction
KDM3B (Lysine Demethylase 3B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include dioxygenase activity. Diseases associated with KDM3B include Persistent Hyperplastic Primary Vitreous. An important paralog of this gene is KDM3A.
Entrez Gene ID
Human51780
Monkey716648
UniProt ID
HumanQ7LBC6
MonkeyI0FSK5
Alternative Names
5qNCA; NET22; C5orf7; JMJD1B
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Biological Process
Chromatin organizationIEA:UniProtKB-KW
Histone H3-K9 demethylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Diets-Jongmans syndrome (DIJOS):
An autosomal dominant disorder characterized by varying degrees of intellectual disability, developmental delay, short stature, and characteristic facial features such as a wide mouth, a pointed chin, long ears and a low columella.

D’Amore, C., Borgo, C., Bosello Travain, V., & Salvi, M. (2022). KDM2A and KDM3B as Potential Targets for the Rescue of F508del-CFTR. International Journal of Molecular Sciences, 23(17), 9612.

Zhu, Z., Wu, X., Li, Q., Zhang, J., Yu, S., Shen, Q., ... & Hua, J. (2021). Histone demethylase complexes KDM3A and KDM3B cooperate with OCT4/SOX2 to define a pluripotency gene regulatory network. The FASEB Journal, 35(6), e21664.

Wang, Y., Zhao, Y., Wang, H., Zhang, C., Wang, M., Yang, Y., ... & Hu, Z. (2020). Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11. FEBS Open Bio, 10(4), 637-643.

Saraç, H., Morova, T., Pires, E., McCullagh, J., Kaplan, A., Cingöz, A., ... & Lack, N. A. (2020). Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. Oncogene, 39(10), 2187-2201.

Zhang, C., Han, X., Liang, Y., Liu, H., Fan, Z., & Zhang, J. (2020). The histone demethylase KDM3B promotes osteo-/odontogenic differentiation, cell proliferation, and migration potential of stem cells from the apical papilla. Stem Cells International, 2020.

Jung, H., & Seo, S. B. (2020). Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes. Plos one, 15(7), e0236403.

An, M. J., Kim, D. H., Kim, C. H., Kim, M., Rhee, S., Seo, S. B., & Kim, J. W. (2019). Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells. Biochemical and biophysical research communications, 508(2), 576-582.

Diets, I. J., van der Donk, R., Baltrunaite, K., Waanders, E., Reijnders, M. R., Dingemans, A. J., ... & Jongmans, M. C. (2019). De novo and inherited pathogenic variants in KDM3B cause intellectual disability, short stature, and facial dysmorphism. The American Journal of Human Genetics, 104(4), 758-766.

Wang, X., Fan, H., Xu, C., Jiang, G., Wang, H., & Zhang, J. (2019). KDM3B suppresses APL progression by restricting chromatin accessibility and facilitating the ATRA-mediated degradation of PML/RARα. Cancer Cell International, 19(1), 1-15.

Xu, X., Nagel, S., Quentmeier, H., Wang, Z., Pommerenke, C., Dirks, W. G., ... & Hu, Z. (2018). KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia. Leukemia & lymphoma, 59(1), 204-213.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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