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Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445)


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Tested Data
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in WB
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in WB
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in IHC
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in IHC
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in IF
Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445) in IF

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2106
Antibody Isotype
IgG1
Application
IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human KDM4A expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Demethylase 4A
Entrez Gene ID
9682
UniProt ID
O75164
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168).
Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively3 Publications
Isoform 2
Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Biological Process
Cardiac muscle hypertrophy in response to stressIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of cell deathIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
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For research use only. Not intended for any clinical use.

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