KDM4A

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
Full Name
Lysine Demethylase 4A
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168).
Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively3 Publications
Isoform 2
Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Biological Process
Cardiac muscle hypertrophy in response to stressIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of astrocyte differentiationIEA:Ensembl
Negative regulation of autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of cell deathIEA:Ensembl
Negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of neuron differentiationIEA:Ensembl
Response to nutrient levelsIEA:Ensembl
Cellular Location
Nucleus
PTM
Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.
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Anti-KDM4A antibodies

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Mouse Anti-KDM4A Recombinant Antibody (CBYJL-034) (CBMAB-L0064-YJ)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-034
Application*: WB, F, E, IH
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (CBYJL-033) (CBMAB-L0063-YJ)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-033
Application*: WB, E, IH, IC, IF, P
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (CBT3544) (V2LY-0625-LY403)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3544
Application*: IC, F
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (CBT801) (V2LY-0625-LY3262)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT801
Application*: WB, P, IF, IC, E
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (CBT2106) (V2LY-0625-LY2445)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2106
Application*: IH, IC
Datasheet SDS

Rabbit Anti-KDM4A Recombinant Antibody (C37E5) (CBMAB-CP1268-LY)

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Target: KDM4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C37E5
Application*: WB, IP, P, IF (IC)
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (13D6) (CBMAB-K0686-LY)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: 13D6
Application*: WB, IP, E, F, CI, IC/IF
Datasheet SDS

Rabbit Anti-KDM4A Recombinant Antibody (CBLY1-066) (CBMAB-K0684-LY)

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Target: KDM4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-066
Application*: WB, IP, P
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (6E10G4) (CBMAB-K0689-LY)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6E10G4
Application*: E, WB, IF/IC, F
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (13B439) (CBMAB-K0685-LY)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B439
Application*: E, IH, WB
Datasheet SDS

Rabbit Anti-KDM4A Recombinant Antibody (C70G6) (CBMAB-0305-WJ)

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Target: KDM4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: C70G6
Application*: WB, IP, IF
Datasheet SDS

Rabbit Anti-KDM4A Recombinant Antibody (C.37.0) (CBMAB-0296-WJ)

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Target: KDM4A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: C.37.0
Application*: IC, IF, IP, WB
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (8C200) (CBMAB-0276-WJ)

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Target: KDM4A
Host: Mouse
Specificity: Human
Clone: 8C200
Application*: WB
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (5H1) (CBMAB-0233-WJ)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5H1
Application*: IC, IF, IH, WB, E
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (3559D5a) (CBMAB-0163-WJ)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3559D5a
Application*: DB, IC
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (CBLXK-005) (CBMAB-2210CQ)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBLXK-005
Application*: WB, IP, IC, IH, F
Datasheet SDS

Mouse Anti-KDM4A Recombinant Antibody (10G8) (CBMAB-0667-CN)

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Target: KDM4A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 10G8
Application*: E, M
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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