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Mouse Anti-KDM4D Recombinant Antibody (F-7) (CBMAB-0355-WJ)

This product is a mouse antibody that recognizes KDM4D. The antibody F-7 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all KDM4D antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
F-7
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lysine Demethylase 4D
Introduction
KDM4D is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include dioxygenase activity and histone demethylase activity (H3-K9 specific). Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. An important paralog of this gene is KDM4F.
Entrez Gene ID
Mouse244694
Rat689582
UniProt ID
MouseQ3U2K5
RatA1A5Q5
Alternative Names
JMJD2D
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Biological Process
Cellular response to ionizing radiationManual Assertion Based On ExperimentIMP:MGI
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:MGI
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Positive regulation of chromatin bindingManual Assertion Based On ExperimentIMP:MGI
Positive regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:MGI
Regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Nucleus

Liu, D., Zhao, Z., She, Y., Zhang, L., Chen, X., Ma, L., & Cui, J. (2022). TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation. Proceedings of the National Academy of Sciences, 119(7), e2113454119.

Yan, H., Zhu, L., Zhang, J., & Lin, Z. (2021). Histone demethylase KDM4D inhibition suppresses renal cancer progression and angiogenesis through JAG1 signaling. Cell Death Discovery, 7(1), 284.

Fang, Z., Liu, Y., Zhang, R., Chen, Q., Wang, T., Yang, W., ... & Yang, S. (2021). Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D. European Journal of Medicinal Chemistry, 223, 113662.

Maitra, S., Khandelwal, N., Kootar, S., Sant, P., Pathak, S. S., Reddy, S., ... & Kumar, A. (2020). Histone lysine demethylase JMJD2D/KDM4D and family members mediate effects of chronic social defeat stress on mouse hippocampal neurogenesis and mood disorders. Brain Sciences, 10(11), 833.

Choi, J. H., & Lee, H. (2020). Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells. Scientific Reports, 10(1), 3050.

Dong, F., Jiang, S., Li, J., Wang, Y., Zhu, L., Huang, Y., ... & Bao, Z. (2019). The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway. EBioMedicine, 39, 472-483.

Isohookana, J., Haapasaari, K. M., Soini, Y., & Karihtala, P. (2018). KDM4D predicts recurrence in exocrine pancreatic cells of resection margins from patients with pancreatic adenocarcinoma. Anticancer Research, 38(4), 2295-2302.

Hu, F., Li, H., Liu, L., Xu, F., Lai, S., Luo, X., ... & Yang, X. (2018). Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling. Molecular Cancer, 17(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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