KDM4D

Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20. Demethylates both di- and trimethylated H3 Lys-9 residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Full Name

Lysine Demethylase 4D

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.

Biological Process

Cellular response to ionizing radiationManual Assertion Based On ExperimentIMP:MGI
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:MGI
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of histone H3-K9 trimethylationIEA:Ensembl
Positive regulation of chromatin bindingManual Assertion Based On ExperimentIMP:MGI
Positive regulation of double-strand break repair via nonhomologous end joiningManual Assertion Based On ExperimentIMP:MGI
Regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Nucleus