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Mouse Anti-KDM5D Recombinant Antibody (4C6) (CBMAB-0210-WJ)

This product is a mouse antibody that recognizes KDM5D. The antibody 4C6 can be used for immunoassay techniques such as: ELISA, WB.
See all KDM5D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C6
Application
ELISA, WB

Basic Information

Immunogen
Paratial recombinant protein corresponding to amino acid 127-230 of JARID1D with GST tag.
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lysine Demethylase 5D
Introduction
KDM5D (Lysine Demethylase 5D) encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Diseases associated with KDM5D include Spermatogenic Failure, Y-Linked, 2. An important paralog of this gene is KDM5C.
Entrez Gene ID
8284
UniProt ID
Q9BY66
Alternative Names
HY; HYA; SMCY; JARID1D
Function
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Biological Process
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
T cell antigen processing and presentationIEA:Ensembl
Cellular Location
Nucleus

Li, J., Lan, Z., Liao, W., Horner, J. W., Xu, X., Liu, J., ... & DePinho, R. A. (2023). Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature, 1-8.

Liu, M., & Gao, N. (2021). KDM5D inhibits the transcriptional activation of FKBP4 by suppressing the expression of E2F1 in colorectal cancer in males. Biochemical Pharmacology, 194, 114814.

Cai, L. S., Chen, Q. X., Fang, S. Y., Lian, M. Q., Lian, M. J., & Cai, M. Z. (2020). ETV4 promotes the progression of gastric cancer through regulating KDM5D. European Review for Medical & Pharmacological Sciences, 24(5).

Kosugi, M., Otani, M., Kikkawa, Y., Itakura, Y., Sakai, K., Ito, T., ... & Kimura, T. (2020). Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice. Biochemical and Biophysical Research Communications, 525(1), 100-106.

Shen, X., Hu, K., Cheng, G., Xu, L., Chen, Z., Du, P., & Zhuang, Z. (2019). KDM5D inhibit epithelial‐mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. Journal of cellular biochemistry, 120(8), 12247-12258.

Meyfour, A., Pahlavan, S., Ansari, H., Baharvand, H., & Salekdeh, G. H. (2019). Down-regulation of a male-specific H3K4 demethylase, KDM5D, impairs cardiomyocyte differentiation. Journal of proteome research, 18(12), 4277-4282.

Mizukami, H., Kim, J. D., Tabara, S., Lu, W., Kwon, C., Nakashima, M., & Fukamizu, A. (2019). KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts. The journal of biochemistry, 165(4), 335-342.

Komura, K., Yoshikawa, Y., Shimamura, T., Chakraborty, G., Gerke, T. A., Hinohara, K., ... & Kantoff, P. W. (2018). ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. The Journal of clinical investigation, 128(7), 2979-2995.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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