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KDM5D

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants.

Full Name

Lysine Demethylase 5D

Function

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Biological Process

Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:MGI
Regulation of androgen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
T cell antigen processing and presentationIEA:Ensembl

Cellular Location

Nucleus

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Anti-KDM5D antibodies

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Mouse Anti-KDM5D Recombinant Antibody (4C6) (CBMAB-0210-WJ)

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Target: KDM5D

Host: Mouse

Specificity: Human

Clone: 4C6

Application*: E, WB

Mouse Anti-KDM5D Recombinant Antibody (4C6) (CBMAB-A4617-LY)

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Target: KDM5D

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4C6

Application*: WB, E

Mouse Anti-KDM5D Recombinant Antibody (CBXS-5005) (CBMAB-S2227-CQ)

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Target: KDM5D

Host: Mouse

Specificity: Human

Clone: CBXS-5005

Application*: WB, IP, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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