Mouse Anti-KIF17 Recombinant Antibody (7C6) (CBMAB-K0847-LY)

This product is antibody recognizes KIF17. The antibody 7C6 immunoassay techniques such as: ELISA, WB.
See all KIF17 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

7C6

Antibody Isotype

IgG2a, κ

Application

ELISA, WB

Basic Information

Immunogen

KIF17 (NP_065867.1, 930 a.a. ~ 1029 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: NMEEDRYRLM LSRSNSENIA SNYFRSKWAS QILSTDARKS LTHHNSPPGL SCPLSNNSAI PPTQAPEMPQ PRPFRLESLD IPFTKAKRKK SKSNFGSEPL

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

kinesin family member 17

Introduction

Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.

Entrez Gene ID

57576

UniProt ID

Q9P2E2

Alternative Names

Kinesin Family Member 17; KIF3-Related Motor Protein; Kinesin-Like Protein KIF17; KIF17 Variant Protein; KIF3X; KIAA1405; KIF17B; KLP-2; OSM-3;

Function

Dendrite-specific motor protein which, in association with the Apba1-containing complex (LIN-10-LIN-2-LIN-7 complex), transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules.

Biological Process

Anterograde dendritic transport of neurotransmitter receptor complexManual Assertion Based On ExperimentIBA:GO_Central
Cell projection organizationManual Assertion Based On ExperimentIBA:GO_Central
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Protein transportIEA:UniProtKB-KW
Vesicle-mediated transportIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, cilium; Cell projection, dendrite. Localizes to dendrites of pyramidal neurons (By similarity).
Does not localize to the axons or nuclei in cerebral cortex, hippocampus or olfactory bulb (By similarity).
Co-localizes with NR2B-containing vesicles along microtubules (By similarity).

References

Waas, B., Carpenter, B. S., Merchant, O. Q., Verhey, K. J., & Allen, B. L. (2022). Dual and Opposing Roles for the Kinesin-2 Motor, KIF17, in Hedgehog-dependent Cerebellar Development. bioRxiv, 2022-08.

Lewis, T. R., Kundinger, S. R., Link, B. A., Insinna, C., & Besharse, J. C. (2018). Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC cell biology, 19(1), 1-16.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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