Rabbit Anti-KIF22 Recombinant Antibody (EP2747Y) (CBMAB-K0860-LY)

Name: Rabbit Anti-KIF22 Recombinant Antibody (EP2747Y)
SKU: CBMAB-K0860-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

EP2747Y

Application

WB, IP, FC

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kinesin family member 22

Introduction

The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Entrez Gene ID

3835

UniProt ID

Q14807

Alternative Names

Kinesin Family Member 22; Kinesin-Like Protein 4; KNSL4; KID; Origin Of Plasmid DNA Replication-Binding Protein; Kinesin-Like DNA-Binding Protein Pseudogene; Kinesin-Like DNA-Binding Protein; Kinesin-Like Protein KIF22;

Function

Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity).
Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).

Biological Process

DNA repairIEA:InterPro
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm, cytoskeleton

Involvement in disease

Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2):
A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood.

PTM

Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Zhong, Z., & Zhong, H. (2023). KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling. Clinics, 78, 100307.

Ren, Y., Yang, B., Guo, G., Zhang, J., Sun, Y., Liu, D., ... & Zhou, Z. (2022). GBP2 facilitates the progression of glioma via regulation of KIF22/EGFR signaling. Cell Death Discovery, 8(1), 208.

Zhang, R., Ma, L., Wei, Y., Wei, K., Song, T., Du, Z., & Feng, Z. (2022). KIF22 promotes development of pancreatic cancer by regulating the MEK/ERK/P21 signaling axis. BioMed Research International, 2022.

Yu, Z. Y., Jiang, X. Y., Zhao, R. R., Qin, J. J., Luo, C. J., Ren, Y. X., ... & Jiao, Z. Y. (2020). Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways. Chinese Medical Journal, 133(08), 919-928.

Liu, Y., Li, R. H., Ren, G., & Jiang, J. (2020). Suppression of KIF22 inhibits cell proliferation and xenograft tumor growth in tongue squamous cell carcinoma. BioMed Research International, 2020.

Li, B., Zhu, F. C., Yu, S. X., Liu, S. J., & Li, B. Y. (2020). Suppression of KIF22 inhibits cell proliferation and xenograft tumor growth in colon cancer. Cancer Biotherapy & Radiopharmaceuticals, 35(1), 50-57.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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