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Rabbit Anti-KIF22 Recombinant Antibody (EP2748) (CBMAB-K0861-LY)

This product is antibody recognizes KIF22. The antibody EP2748 immunoassay techniques such as: WB.
See all KIF22 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EP2748
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kinesin family member 22
Introduction
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Entrez Gene ID
UniProt ID
Alternative Names
Kinesin Family Member 22; Kinesin-Like Protein 4; KNSL4; KID; Origin Of Plasmid DNA Replication-Binding Protein; Kinesin-Like DNA-Binding Protein Pseudogene; Kinesin-Like DNA-Binding Protein; Kinesin-Like Protein KIF22;
Function
Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity).
Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205).
Biological Process
DNA repairIEA:InterPro
Metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Sister chromatid cohesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus; Cytoplasm, cytoskeleton
Involvement in disease
Spondyloepimetaphyseal dysplasia with joint laxity, 2 (SEMDJL2):
A bone disease characterized by short stature, distinctive midface retrusion, progressive knee malalignment (genu valgum and/or varum), generalized ligamentous laxity, and mild spinal deformity. Intellectual development is not impaired. Radiographic characteristics include significantly retarded epiphyseal ossification that evolves into epiphyseal dysplasia and precocious osteoarthritis, metaphyseal irregularities and vertical striations, constricted femoral neck, slender metacarpals and metatarsals, and mild thoracolumbar kyphosis or scoliosis with normal or mild platyspondyly. The most distinctive features for differential diagnosis of SEMDJL2 are the slender metacarpals and phalanges and the progressive degeneration of carpal bones; however, these 2 features are evident only in older children and young adults. The soft consistency of cartilage in the airways leads to laryngotracheomalacia with proneness to respiratory obstruction and inspiratory stridor in infancy and childhood.
PTM
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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