Rabbit Anti-KIFC1 Recombinant Antibody (11445) (CBMAB-K0902-LY)

Name: Rabbit Anti-KIFC1 Recombinant Antibody (11445)
SKU: CBMAB-K0902-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

11445

Application

WB, IHC-P, IP, ICC/IF

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kinesin Family Member C1

Introduction

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

Entrez Gene ID

3833

UniProt ID

Q9BW19

Alternative Names

Kinesin Family Member C1; Kinesin-Related Protein HSET; Kinesin-Like Protein 2; Kinesin-Like 2; KNSL2; HSET; Kinesin-Like Protein KIFC1;

Function

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429).
May contribute to movement of early endocytic vesicles (By similarity).
Regulates cilium formation and structure (By similarity).

Biological Process

Cell divisionIEA:UniProtKB-KW
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic sister chromatid segregation1 PublicationNAS:UniProtKB
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle; Early endosome. Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.

Sharma, N., Setiawan, D., Hamelberg, D., Narayan, R., & Aneja, R. (2023). Computational benchmarking of putative KIFC1 inhibitors. Medicinal Research Reviews, 43(2), 293-318.

Muralidharan, H., Guha, S., Madugula, K., Patil, A., Bennison, S. A., Sun, X., ... & Baas, P. W. (2022). KIFC1 regulates the trajectory of neuronal migration. Journal of Neuroscience, 42(11), 2149-2165.

Li, D., Yu, T., Han, J., Xu, X., Wu, J., Song, W., ... & Zeng, Z. (2022). Prognostic value and immunological role of KIFC1 in hepatocellular carcinoma. Frontiers in Molecular Biosciences, 8, 799651.

Kostecka, L. G., Olseen, A., Kang, K., Torga, G., Pienta, K. J., & Amend, S. R. (2021). High KIFC1 expression is associated with poor prognosis in prostate cancer. Medical Oncology, 38, 1-9.

Han, J., Wang, F., Lan, Y., Wang, J., Nie, C., Liang, Y., ... & Liu, L. (2019). KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. Oncogene, 38(3), 406-420.

Sekino, Y., Oue, N., Koike, Y., Shigematsu, Y., Sakamoto, N., Sentani, K., ... & Yasui, W. (2019). KIFC1 inhibitor CW069 induces apoptosis and reverses resistance to docetaxel in prostate cancer. Journal of Clinical Medicine, 8(2), 225.

Muralidharan, H., & Baas, P. W. (2019). Mitotic motor KIFC1 is an organizer of microtubules in the axon. Journal of Neuroscience, 39(20), 3792-3811.

Lee, S. H., Too, K., Jung, E. J., Hong, H., Seo, J., & Kim, J. (2018). Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. The FASEB Journal, 32(2), 957-968.

Fu, X., Zhu, Y., Zheng, B., Zou, Y., Wang, C., Wu, P., ... & Fang, L. (2018). KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma. International Journal of Oncology, 52(6), 1912-1922.

Li, G., Chong, T., Yang, J., Li, H., & Chen, H. (2018). Kinesin motor protein KIFC1 is a target protein of miR-338-3p and is associated with poor prognosis and progression of renal cell carcinoma. Oncology research, 27(1), 125.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Human KIFC1 ELISA Kit (CAT#: V2LY-0626-LY5658)

Mouse Anti-KIFC1 Recombinant Antibody (2B9) (CAT#: CBMAB-K0903-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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