Human KIFC1 ELISA Kit (V2LY-0626-LY5658)

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Tested Data
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Basic Information

Sensitivity
0.0079 ng/mL
Detection Range
0.015-3 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
73.7 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Kinesin Family Member C1
Function
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429).
May contribute to movement of early endocytic vesicles (By similarity).
Regulates cilium formation and structure (By similarity).
Biological Process
Cell divisionIEA:UniProtKB-KW
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic metaphase plate congressionManual Assertion Based On ExperimentIMP:UniProtKB
Mitotic sister chromatid segregation1 PublicationNAS:UniProtKB
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle; Early endosome. Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.

Sharma, N., Setiawan, D., Hamelberg, D., Narayan, R., & Aneja, R. (2023). Computational benchmarking of putative KIFC1 inhibitors. Medicinal Research Reviews, 43(2), 293-318.

Muralidharan, H., Guha, S., Madugula, K., Patil, A., Bennison, S. A., Sun, X., ... & Baas, P. W. (2022). KIFC1 regulates the trajectory of neuronal migration. Journal of Neuroscience, 42(11), 2149-2165.

Li, D., Yu, T., Han, J., Xu, X., Wu, J., Song, W., ... & Zeng, Z. (2022). Prognostic value and immunological role of KIFC1 in hepatocellular carcinoma. Frontiers in Molecular Biosciences, 8, 799651.

Kostecka, L. G., Olseen, A., Kang, K., Torga, G., Pienta, K. J., & Amend, S. R. (2021). High KIFC1 expression is associated with poor prognosis in prostate cancer. Medical Oncology, 38, 1-9.

Han, J., Wang, F., Lan, Y., Wang, J., Nie, C., Liang, Y., ... & Liu, L. (2019). KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling. Oncogene, 38(3), 406-420.

Sekino, Y., Oue, N., Koike, Y., Shigematsu, Y., Sakamoto, N., Sentani, K., ... & Yasui, W. (2019). KIFC1 inhibitor CW069 induces apoptosis and reverses resistance to docetaxel in prostate cancer. Journal of Clinical Medicine, 8(2), 225.

Muralidharan, H., & Baas, P. W. (2019). Mitotic motor KIFC1 is an organizer of microtubules in the axon. Journal of Neuroscience, 39(20), 3792-3811.

Lee, S. H., Too, K., Jung, E. J., Hong, H., Seo, J., & Kim, J. (2018). Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1. The FASEB Journal, 32(2), 957-968.

Fu, X., Zhu, Y., Zheng, B., Zou, Y., Wang, C., Wu, P., ... & Fang, L. (2018). KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma. International Journal of Oncology, 52(6), 1912-1922.

Li, G., Chong, T., Yang, J., Li, H., & Chen, H. (2018). Kinesin motor protein KIFC1 is a target protein of miR-338-3p and is associated with poor prognosis and progression of renal cell carcinoma. Oncology research, 27(1), 125.

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For research use only. Not intended for any clinical use.

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