Sign in or Register   Sign in or Register
  |  

Mouse Anti-KIR2DL1 Recombinant Antibody (NKVFS1) (CBMAB-K0084-LY)

This product is antibody recognizes KIR2DL1. The antibody NKVFS1 immunoassay techniques such as: WB, FC, ELISA, IP.
See all KIR2DL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
NKVFS1
Antibody Isotype
IgG1
Application
WB, FC, ELISA, IP

Basic Information

Immunogen
Made to Human KIR
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Long Cytoplasmic Tail 1; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Long Cytoplasmic Tail; 1; P58 Natural Killer Cell Receptor Clones CL-42/47.11; Natural Killer-Associated Transcript 1; P58.1 MHC Class-I-Specific NK Receptor; CD158 Antigen-Like Family Member A; MHC Class I NK Cell Receptor; P58 NK Receptor CL-42/47.11; CD158A; NKAT-1; NKAT1; Killer Cell Immunoglobulin-Like Receptor 2DL1;
Function
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-264
Cytoplasmic: 265-348

Wright, P. W., Li, H., Rahman, M. A., Anderson, E. M., Karwan, M., Carrell, J., & Anderson, S. K. (2023). The KIR2DL1 intermediate upstream element participates in gene activation. Immunogenetics, 1-12.

Meazza, R., Falco, M., Canevali, P., Loiacono, F., Colomar‐Carando, N., Muntasell, A., ... & Pende, D. (2022). Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA‐C. HLA, 100(2), 119-132.

Wang, X., Liu, Y., Lu, Y., Chen, S., Xing, Y., Yang, H., ... & Zhou, F. (2022). Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma. Annals of Medicine, 54(1), 51-62.

Vargas, L. D. B., Dourado, R. M., Amorim, L. M., Ho, B., Calonga-Solís, V., Issler, H. C., ... & Augusto, D. G. (2020). Single nucleotide polymorphism in KIR2DL1 is associated with HLA-C expression in global populations. Frontiers in Immunology, 1881.

Le Luduec, J. B., Boudreau, J. E., Freiberg, J. C., & Hsu, K. C. (2019). Novel approach to cell surface discrimination between KIR2DL1 subtypes and KIR2DS1 identifies hierarchies in NK repertoire, education, and tolerance. Frontiers in Immunology, 10, 734.

Lisovsky, I., Kant, S., Tremblay-McLean, A., Isitman, G., Kiani, Z., Dupuy, F. P., ... & Bernard, N. F. (2019). Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. Journal of leukocyte biology, 105(3), 551-563.

Huhn, O., Chazara, O., Ivarsson, M. A., Retiere, C., Venkatesan, T. C., Norman, P. J., ... & Colucci, F. (2018). High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia. The Journal of Immunology, 201(9), 2593-2601.

Castellana, B., Perdu, S., Kim, Y., Chan, K., Atif, J., Marziali, M., & Beristain, A. G. (2018). Maternal obesity alters uterine NK activity through a functional KIR2DL1/S1 imbalance. Immunology and Cell Biology, 96(8), 805-819.

Nemat-Gorgani, N., Hilton, H. G., Henn, B. M., Lin, M., Gignoux, C. R., Myrick, J. W., ... & Norman, P. J. (2018). Different selected mechanisms attenuated the inhibitory interaction of KIR2DL1 with C2+ HLA-C in two indigenous human populations in Southern Africa. The Journal of Immunology, 200(8), 2640-2655.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-KIR2DL1 Recombinant Antibody (NKVFS1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare