KIR2DL1

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Full Name
Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1
Function
Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-245
Helical: 246-264
Cytoplasmic: 265-348
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Anti-KIR2DL1 antibodies

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Mouse Anti-KIR2DL1 Recombinant Antibody (6H2) (CBMAB-K0912-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6H2
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-KIR2DL1 Recombinant Antibody (124) (CBMAB-K0090-LY)

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Target: KIR2DL1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 124
Application*: F
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (MM0439-8J29) (CBMAB-K0088-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0439-8J29
Application*: F, MC
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (2F9) (CBMAB-K0087-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F9
Application*: WB, E
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (NKVFS1) (CBMAB-K0084-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKVFS1
Application*: WB, F, E, IP
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (MM0438-11G25) (CBMAB-K0083-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0438-11G25
Application*: F
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (180704) (CBMAB-K0082-LY)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 180704
Application*: F
Datasheet SDS

Mouse Anti-KIR2DL1 Recombinant Antibody (CBWJC-2259) (CBMAB-C3102WJ)

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Target: KIR2DL1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBWJC-2259
Application*: F, C
Datasheet SDS

Human Anti-KIR2DL1 Recombinant Antibody (CBXC-0789) (CBMAB-C1903-CQ)

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Target: KIR2DL1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0789
Application*: F
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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