Human Recombinant KIR2DL1 protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY5166)

Name: Human Recombinant KIR2DL1 protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY5166
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant KIR2DL1 protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-245 and predicts a molecular mass of 27.94 kDa.

Molecule Mass

27.94 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-245

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Long Cytoplasmic Tail 1

Function

Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.

Biological Process

Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Natural killer cell inhibitory signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 22-245
Helical: 246-264
Cytoplasmic: 265-348

Wright, P. W., Li, H., Rahman, M. A., Anderson, E. M., Karwan, M., Carrell, J., & Anderson, S. K. (2023). The KIR2DL1 intermediate upstream element participates in gene activation. Immunogenetics, 1-12.

Meazza, R., Falco, M., Canevali, P., Loiacono, F., Colomar‐Carando, N., Muntasell, A., ... & Pende, D. (2022). Characterization of KIR+ NK cell subsets with a monoclonal antibody selectively recognizing KIR2DL1 and blocking the specific interaction with HLA‐C. HLA, 100(2), 119-132.

Wang, X., Liu, Y., Lu, Y., Chen, S., Xing, Y., Yang, H., ... & Zhou, F. (2022). Clinical impact of Fn-induced high expression of KIR2DL1 in CD8 T lymphocytes in oesophageal squamous cell carcinoma. Annals of Medicine, 54(1), 51-62.

Vargas, L. D. B., Dourado, R. M., Amorim, L. M., Ho, B., Calonga-Solís, V., Issler, H. C., ... & Augusto, D. G. (2020). Single nucleotide polymorphism in KIR2DL1 is associated with HLA-C expression in global populations. Frontiers in Immunology, 1881.

Le Luduec, J. B., Boudreau, J. E., Freiberg, J. C., & Hsu, K. C. (2019). Novel approach to cell surface discrimination between KIR2DL1 subtypes and KIR2DS1 identifies hierarchies in NK repertoire, education, and tolerance. Frontiers in Immunology, 10, 734.

Lisovsky, I., Kant, S., Tremblay-McLean, A., Isitman, G., Kiani, Z., Dupuy, F. P., ... & Bernard, N. F. (2019). Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. Journal of leukocyte biology, 105(3), 551-563.

Huhn, O., Chazara, O., Ivarsson, M. A., Retiere, C., Venkatesan, T. C., Norman, P. J., ... & Colucci, F. (2018). High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia. The Journal of Immunology, 201(9), 2593-2601.

Castellana, B., Perdu, S., Kim, Y., Chan, K., Atif, J., Marziali, M., & Beristain, A. G. (2018). Maternal obesity alters uterine NK activity through a functional KIR2DL1/S1 imbalance. Immunology and Cell Biology, 96(8), 805-819.

Nemat-Gorgani, N., Hilton, H. G., Henn, B. M., Lin, M., Gignoux, C. R., Myrick, J. W., ... & Norman, P. J. (2018). Different selected mechanisms attenuated the inhibitory interaction of KIR2DL1 with C2+ HLA-C in two indigenous human populations in Southern Africa. The Journal of Immunology, 200(8), 2640-2655.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KIR2DL1 protein, hFc Tag (CAT#: V2LY-0526-LY5165)

Human Recombinant KIR2DL1 protein, His Tag (CAT#: V2LY-0526-LY5167)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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