Rabbit Anti-KIR2DS5 Recombinant Antibody (1165A) (CBMAB-K0110-LY)

Name: Rabbit Anti-KIR2DS5 Recombinant Antibody (1165A)
SKU: CBMAB-K0110-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

1165A

Application

Immunogen

NS0 mouse myeloma cell line transfected with human KIR2DS5/CD158g, His22-His245

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Two Ig Domains And Short Cytoplasmic Tail 5

Introduction

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

Entrez Gene ID

3810

UniProt ID

Q14953

Alternative Names

Killer Cell Immunoglobulin Like Receptor; Two Ig Domains And Short Cytoplasmic Tail 5; Killer Cell Immunoglobulin-Like Receptor; Two Domains; Short Cytoplasmic Tail; 5; Natural Killer-Associated Transcript 9; CD158 Antigen-Like Family Member G; CD158G; NKAT-9; NKAT9;

Function

Activating natural killer (NK) receptor that recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express a number of cell surface receptors which either inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925).
Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691).
Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).

Biological Process

Immune response1 PublicationNAS:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 22-245
Helical: 246-265
Cytoplasmic: 266-304

PTM

N-glycosylated, glycosylation varies depending on the allele which alters cell surface expression levels.

Margolis, D. J., Mitra, N., Hoffstad, O. J., Berna, R., Kim, B. S., Chopra, A., & Phillips, E. J. (2023). Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis. Scientific Reports, 13(1), 1730.

Wei, X., & Yang, X. (2023). The novel role of activating receptor KIR2DS5 in preeclampsia. International Immunopharmacology, 125, 111087.

Legaz, I., Bolarín, J. M., Navarro, E., Campillo, J. A., Moya, R., Pérez-Cárceles, M. D., ... & López, R. A. (2021). KIR2DL2/S2 and KIR2DS5 in alcoholic cirrhotic patients undergoing liver transplantation. Archives of Medical Science: AMS, 17(3), 764.

Barani, S., Taghipour, M., & Ghaderi, A. (2020). Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma. Immunobiology, 225(2), 151900.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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