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Mouse Anti-KIR3DL1 Recombinant Antibody (DX9) (CBMAB-K0112-LY)

This product is antibody recognizes KIR3DL1. The antibody DX9 immunoassay techniques such as: Blocking, FC, ICC, IHC-Fr, IHC-P, IP.
See all KIR3DL1 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
DX9
Antibody Isotype
IgG1
Application
Blocking, FC, ICC, IHC-Fr, IHC-P, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Three Ig Domains And Long Cytoplasmic Tail 1; Killer Cell Immunoglobulin-Like Receptor; Three Domains; Long Cytoplasmic Tail; 1; P70 Natural Killer Cell Receptor Clones CL-2/CL-11; HLA-BW4-Specific Inhibitory NK Cell Receptor; Natural Killer-Associated Transcript 3; CD158 Antigen-Like Family Member E; P70 NK Receptor CL-2/CL-11; NKAT-3; NKAT3; NKB1; Killer Cell Immunoglobulin-Like Receptor 3DL1;
Function
Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune response2 PublicationsNAS:UniProtKB
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-444

Muriuki, B. M., Forconi, C. S., Kirwa, E. K., Maina, T. K., Ariera, B. O., Bailey, J. A., ... & Ong’echa, J. M. (2023). Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma. Plos one, 18(8), e0275046.

Harrison, G. F., Leaton, L. A., Harrison, E. A., Kichula, K. M., Viken, M. K., Shortt, J., ... & Norman, P. J. (2022). Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1. PLoS Computational Biology, 18(2), e1009059.

Izumi, K., Shindo, T., Ngo, H. T., Nakayama-Hosoya, K., Akahane, K., Tamai, M., ... & Takaori-Kondo, A. (2021). KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia. ImmunoHorizons, 5(8), 687-702.

Schetelig, J., Baldauf, H., Heidenreich, F., Massalski, C., Frank, S., Sauter, J., ... & Bornhäuser, M. (2020). External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails. Blood, The Journal of the American Society of Hematology, 135(16), 1386-1395.

Geng, J., & Raghavan, M. (2019). CD8αα homodimers function as a coreceptor for KIR3DL1. Proceedings of the National Academy of Sciences, 116(36), 17951-17956.

Lisovsky, I., Kant, S., Tremblay-McLean, A., Isitman, G., Kiani, Z., Dupuy, F. P., ... & Bernard, N. F. (2019). Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. Journal of leukocyte biology, 105(3), 551-563.

Castaño-Núñez, Á., Montes-Cano, M. A., García-Lozano, J. R., Ortego-Centeno, N., García-Hernández, F. J., Espinosa, G., ... & González-Escribano, M. F. (2019). Association of functional polymorphisms of KIR3DL1/DS1 with Behcet's disease. Frontiers in immunology, 10, 2755.

Petrushkin, H., Norman, P. J., Lougee, E., Parham, P., Wallace, G. R., Stanford, M. R., & Fortune, F. (2019). KIR3DL1/S1 allotypes contribute differentially to the development of Behçet disease. The Journal of Immunology, 203(6), 1629-1635.

Pugh, J., Nemat-Gorgani, N., Djaoud, Z., Guethlein, L. A., Norman, P. J., & Parham, P. (2019). In vitro education of human natural killer cells by KIR3DL1. Life Science Alliance, 2(6).

Zhang, X., Lu, X., Moog, C., Yuan, L., Liu, Z., Li, Z., ... & Su, B. (2018). KIR3DL1-negative CD8 T cells and KIR3DL1-negative natural killer cells contribute to the advantageous control of early human immunodeficiency virus type 1 infection in HLA-B Bw4 homozygous individuals. Frontiers in Immunology, 9, 1855.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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