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KIR3DL1

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Full Name
Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1
Function
Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune response2 PublicationsNAS:UniProtKB
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-444
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Anti-KIR3DL1 antibodies

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Mouse Anti-KIR3DL1 Recombinant Antibody (7G33) (CBMAB-K0942-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7G33
Application*: E, WB
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBT2867) (V2LY-0625-LY844)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2867
Application*: IH, F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBT3144) (V2LY-0625-LY843)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3144
Application*: F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBT3548) (V2LY-0625-LY833)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: CBT3548
Application*: WB, F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBT3056) (V2LY-0625-LY832)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Rat
Clone: CBT3056
Application*: WB, IH
Datasheet SDS

Human Anti-KIR3DL1 Recombinant Antibody (CBXC-0726) (CBMAB-C1840-CQ)

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Target: KIR3DL1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0726
Application*: F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBXC-2580) (CBMAB-C1680-CQ)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2580
Application*: F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (14L673) (CBMAB-K0940-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L673
Application*: F, N
Functional Assay
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (14L668) (CBMAB-K0939-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 14L668
Application*: F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (13H296) (CBMAB-K0938-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13H296
Application*: E, WB
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (CBLY1-098) (CBMAB-K0937-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-098
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (MM0443-1L34) (CBMAB-K0113-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0443-1L34
Application*: F
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (DX9) (CBMAB-K0112-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: DX9
Application*: B, F, IC, C, P, IP
Functional Assay
Datasheet SDS

Mouse Anti-KIR3DL1 Recombinant Antibody (177407) (CBMAB-K0111-LY)

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Target: KIR3DL1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 177407
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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