Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-KIR3DL1 Recombinant Antibody (CBT3548) (V2LY-0625-LY833)


See all KIR3DL1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBT3548
Antibody Isotype
IgG2b
Application
WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human KIR3DL1 (AA: extra 22-340) expressed in HEK293 cells.
Host Species
Mouse
Specificity
Human, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1
Entrez Gene ID
3811
UniProt ID
P43629
Function
Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Biological Process
Immune response2 PublicationsNAS:UniProtKB
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-444
More Infomation

Muriuki, B. M., Forconi, C. S., Kirwa, E. K., Maina, T. K., Ariera, B. O., Bailey, J. A., ... & Ong’echa, J. M. (2023). Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma. Plos one, 18(8), e0275046.

Harrison, G. F., Leaton, L. A., Harrison, E. A., Kichula, K. M., Viken, M. K., Shortt, J., ... & Norman, P. J. (2022). Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1. PLoS Computational Biology, 18(2), e1009059.

Izumi, K., Shindo, T., Ngo, H. T., Nakayama-Hosoya, K., Akahane, K., Tamai, M., ... & Takaori-Kondo, A. (2021). KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia. ImmunoHorizons, 5(8), 687-702.

Schetelig, J., Baldauf, H., Heidenreich, F., Massalski, C., Frank, S., Sauter, J., ... & Bornhäuser, M. (2020). External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails. Blood, The Journal of the American Society of Hematology, 135(16), 1386-1395.

Geng, J., & Raghavan, M. (2019). CD8αα homodimers function as a coreceptor for KIR3DL1. Proceedings of the National Academy of Sciences, 116(36), 17951-17956.

Lisovsky, I., Kant, S., Tremblay-McLean, A., Isitman, G., Kiani, Z., Dupuy, F. P., ... & Bernard, N. F. (2019). Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. Journal of leukocyte biology, 105(3), 551-563.

Castaño-Núñez, Á., Montes-Cano, M. A., García-Lozano, J. R., Ortego-Centeno, N., García-Hernández, F. J., Espinosa, G., ... & González-Escribano, M. F. (2019). Association of functional polymorphisms of KIR3DL1/DS1 with Behcet's disease. Frontiers in immunology, 10, 2755.

Petrushkin, H., Norman, P. J., Lougee, E., Parham, P., Wallace, G. R., Stanford, M. R., & Fortune, F. (2019). KIR3DL1/S1 allotypes contribute differentially to the development of Behçet disease. The Journal of Immunology, 203(6), 1629-1635.

Pugh, J., Nemat-Gorgani, N., Djaoud, Z., Guethlein, L. A., Norman, P. J., & Parham, P. (2019). In vitro education of human natural killer cells by KIR3DL1. Life Science Alliance, 2(6).

Zhang, X., Lu, X., Moog, C., Yuan, L., Liu, Z., Li, Z., ... & Su, B. (2018). KIR3DL1-negative CD8 T cells and KIR3DL1-negative natural killer cells contribute to the advantageous control of early human immunodeficiency virus type 1 infection in HLA-B Bw4 homozygous individuals. Frontiers in Immunology, 9, 1855.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KIR3DL1 Recombinant Antibody (CBT3548)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry