Human Recombinant KIR3DL1 protein, ECD, hFc Tag (V2LY-0526-LY5173)

Name: Human Recombinant KIR3DL1 protein, ECD, hFc Tag
SKU: V2LY-0526-LY5173
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant KIR3DL1 protein, ECD, hFc Tag consist of Amino Acid: 1-340 and predicts a molecular mass of 61.92 kDa.

Molecule Mass

61.92 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 1-340

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1

Function

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Biological Process

Immune response2 PublicationsNAS:UniProtKB
Natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-444

Muriuki, B. M., Forconi, C. S., Kirwa, E. K., Maina, T. K., Ariera, B. O., Bailey, J. A., ... & Ong’echa, J. M. (2023). Evaluation of KIR3DL1/KIR3DS1 allelic polymorphisms in Kenyan children with endemic Burkitt lymphoma. Plos one, 18(8), e0275046.

Harrison, G. F., Leaton, L. A., Harrison, E. A., Kichula, K. M., Viken, M. K., Shortt, J., ... & Norman, P. J. (2022). Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1. PLoS Computational Biology, 18(2), e1009059.

Izumi, K., Shindo, T., Ngo, H. T., Nakayama-Hosoya, K., Akahane, K., Tamai, M., ... & Takaori-Kondo, A. (2021). KIR3DL1 Allotype-Dependent Modulation of NK Cell Immunity against Chronic Myeloid Leukemia. ImmunoHorizons, 5(8), 687-702.

Schetelig, J., Baldauf, H., Heidenreich, F., Massalski, C., Frank, S., Sauter, J., ... & Bornhäuser, M. (2020). External validation of models for KIR2DS1/KIR3DL1-informed selection of hematopoietic cell donors fails. Blood, The Journal of the American Society of Hematology, 135(16), 1386-1395.

Geng, J., & Raghavan, M. (2019). CD8αα homodimers function as a coreceptor for KIR3DL1. Proceedings of the National Academy of Sciences, 116(36), 17951-17956.

Lisovsky, I., Kant, S., Tremblay-McLean, A., Isitman, G., Kiani, Z., Dupuy, F. P., ... & Bernard, N. F. (2019). Differential contribution of education through KIR2DL1, KIR2DL3, and KIR3DL1 to antibody-dependent (AD) NK cell activation and ADCC. Journal of leukocyte biology, 105(3), 551-563.

Castaño-Núñez, Á., Montes-Cano, M. A., García-Lozano, J. R., Ortego-Centeno, N., García-Hernández, F. J., Espinosa, G., ... & González-Escribano, M. F. (2019). Association of functional polymorphisms of KIR3DL1/DS1 with Behcet's disease. Frontiers in immunology, 10, 2755.

Petrushkin, H., Norman, P. J., Lougee, E., Parham, P., Wallace, G. R., Stanford, M. R., & Fortune, F. (2019). KIR3DL1/S1 allotypes contribute differentially to the development of Behçet disease. The Journal of Immunology, 203(6), 1629-1635.

Pugh, J., Nemat-Gorgani, N., Djaoud, Z., Guethlein, L. A., Norman, P. J., & Parham, P. (2019). In vitro education of human natural killer cells by KIR3DL1. Life Science Alliance, 2(6).

Zhang, X., Lu, X., Moog, C., Yuan, L., Liu, Z., Li, Z., ... & Su, B. (2018). KIR3DL1-negative CD8 T cells and KIR3DL1-negative natural killer cells contribute to the advantageous control of early human immunodeficiency virus type 1 infection in HLA-B Bw4 homozygous individuals. Frontiers in Immunology, 9, 1855.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human KIR3DL1 ELISA Kit (CAT#: V2LY-0626-LY4)

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Isotype control

For research use only. Not intended for any clinical use.

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