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Rabbit Anti-KIR3DL3 Recombinant Antibody (1136B) (CBMAB-K0115-LY)

This product is antibody recognizes KIR3DL3. The antibody 1136B immunoassay techniques such as: FC.
See all KIR3DL3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
1136B
Antibody Isotype
IgG
Application
FC

Basic Information

Immunogen
Human embryonic kidney cell line HEK293-derived recombinant human KIR3DL3/CD158z, Met1-Leu322
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA
Preservative
Sodium Azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Three Ig Domains And Long Cytoplasmic Tail 3; Killer Cell Immunoglobulin-Like Receptor; Three Domains; Long Cytoplasmic Tail; 3; CD158 Antigen-Like Family Member Z; Killer Cell Inhibitory Receptor 1; KIR3DL7; CD158Z; KIRC1;
Function
Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.
Cellular Location
Cell membrane
Topology
Extracellular: 26-322
Helical: 323-343
Cytoplasmic: 344-410

Palmer, W. H., Leaton, L. A., Campos Codo, A., Crute, B., Roest, J., Zhu, S., ... & Norman, P. J. (2023). Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Science Immunology, 8(84), eade5343.

Li, Y., Lv, C., Yu, Y., Wu, B., Zhang, Y., Lang, Q., ... & Tian, Y. (2023). KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. Journal of advanced research, 47, 137-150.

Lamb, M., Wei, Y., Ren, X., O'Connor, R., Dulak, A., Rausch, M., ... & Zang, X. (2022). 489 NPX267, a first-in-class monoclonal antibody targeting KIR3DL3, blocks HHLA2-mediated immunosuppression and potentiates T and NK cell-mediated antitumor immunity.

Wei, Y., Ren, X., Galbo Jr, P. M., Moerdler, S., Wang, H., Sica, R. A., ... & Zang, X. (2021). KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target. Science immunology, 6(61), eabf9792.

Bhatt, R. S., Berjis, A., Konge, J. C., Mahoney, K. M., Klee, A. N., Freeman, S. S., ... & Freeman, G. J. (2021). KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1. Cancer immunology research, 9(2), 156-169.

Campbell, K. S. (2021). Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2. Cancer Immunology Research, 9(2), 128-128.

Nutalai, R., Gaudieri, S., Jumnainsong, A., & Leelayuwat, C. (2019). Regulation of KIR3DL3 expression via mirna. Genes, 10(8), 603.

Leaton, L. A., Shortt, J., Kichula, K. M., Tao, S., Nemat-Gorgani, N., Mentzer, A. J., ... & Norman, P. J. (2019). Conservation, extensive heterozygosity, and convergence of signaling potential all indicate a critical role for KIR3DL3 in higher primates. Frontiers in Immunology, 10, 24.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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