Rabbit Anti-KIR3DL3 Recombinant Antibody (1136B) (CBMAB-K0115-LY)

Name: Rabbit Anti-KIR3DL3 Recombinant Antibody (1136B)
SKU: CBMAB-K0115-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

1136B

Application

Immunogen

Human embryonic kidney cell line HEK293-derived recombinant human KIR3DL3/CD158z, Met1-Leu322

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA

Preservative

Sodium Azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 3

Introduction

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. [provided by RefSeq, Jul 2008]

Entrez Gene ID

115653

UniProt ID

Q8N743

Alternative Names

Killer Cell Immunoglobulin Like Receptor; Three Ig Domains And Long Cytoplasmic Tail 3; Killer Cell Immunoglobulin-Like Receptor; Three Domains; Long Cytoplasmic Tail; 3; CD158 Antigen-Like Family Member Z; Killer Cell Inhibitory Receptor 1; KIR3DL7; CD158Z; KIRC1;

Function

Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.

Cellular Location

Cell membrane

Topology

Extracellular: 26-322
Helical: 323-343
Cytoplasmic: 344-410

Palmer, W. H., Leaton, L. A., Campos Codo, A., Crute, B., Roest, J., Zhu, S., ... & Norman, P. J. (2023). Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. Science Immunology, 8(84), eade5343.

Li, Y., Lv, C., Yu, Y., Wu, B., Zhang, Y., Lang, Q., ... & Tian, Y. (2023). KIR3DL3-HHLA2 and TMIGD2-HHLA2 pathways: The dual role of HHLA2 in immune responses and its potential therapeutic approach for cancer immunotherapy. Journal of advanced research, 47, 137-150.

Lamb, M., Wei, Y., Ren, X., O'Connor, R., Dulak, A., Rausch, M., ... & Zang, X. (2022). 489 NPX267, a first-in-class monoclonal antibody targeting KIR3DL3, blocks HHLA2-mediated immunosuppression and potentiates T and NK cell-mediated antitumor immunity.

Wei, Y., Ren, X., Galbo Jr, P. M., Moerdler, S., Wang, H., Sica, R. A., ... & Zang, X. (2021). KIR3DL3-HHLA2 is a human immunosuppressive pathway and a therapeutic target. Science immunology, 6(61), eabf9792.

Bhatt, R. S., Berjis, A., Konge, J. C., Mahoney, K. M., Klee, A. N., Freeman, S. S., ... & Freeman, G. J. (2021). KIR3DL3 is an inhibitory receptor for HHLA2 that mediates an alternative immunoinhibitory pathway to PD1. Cancer immunology research, 9(2), 156-169.

Campbell, K. S. (2021). Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2. Cancer Immunology Research, 9(2), 128-128.

Nutalai, R., Gaudieri, S., Jumnainsong, A., & Leelayuwat, C. (2019). Regulation of KIR3DL3 expression via mirna. Genes, 10(8), 603.

Leaton, L. A., Shortt, J., Kichula, K. M., Tao, S., Nemat-Gorgani, N., Mentzer, A. J., ... & Norman, P. J. (2019). Conservation, extensive heterozygosity, and convergence of signaling potential all indicate a critical role for KIR3DL3 in higher primates. Frontiers in Immunology, 10, 24.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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