Sign in or Register   Sign in or Register
  |  

Rabbit Anti-KLC1 Recombinant Antibody (D2T2R) (CBMAB-CP1307-LY)

The product is antibody recognizes KLC1. The antibody D2T2R immunoassay techniques such as: WB,IP.
See all KLC1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D2T2R
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly443 of human KLC1 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Light Chain 1
Introduction
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3831
UniProt ID
Q07866
Alternative Names
Kinesin Light Chain 1; Kinesin 2 60/70kDa; KNS2; KLC; Medulloblastoma Antigen MU-MB-2.50; Kinesin 2; KNS2A; KLC 1;
Function
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Biological Process
Stress granule disassemblyISS:BHF-UCL
Cellular Location
Cell projection, growth cone; Cytoplasm, cytoskeleton

Antón, Z., Weijman, J. F., Williams, C., Moody, E. R., Mantell, J., Yip, Y. Y., ... & Dodding, M. P. (2021). Molecular mechanism for kinesin-1 direct membrane recognition. Science Advances, 7(31), eabg6636.

Saez, T. M., Fernandez Bessone, I., Rodriguez, M. S., Alloatti, M., Otero, M. G., Cromberg, L. E., ... & Falzone, T. L. (2020). Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance. Development, 147(8), dev184069.

Moamer, A., Hachim, I. Y., Binothman, N., Wang, N., Lebrun, J. J., & Ali, S. (2019). A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis. EBioMedicine, 45, 92-107.

Mórotz, G. M., Glennon, E. B., Greig, J., Lau, D. H., Bhembre, N., Mattedi, F., ... & Miller, C. C. (2019). Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein. Acta neuropathologica communications, 7, 1-13.

Cockburn, J. J., Hesketh, S. J., Mulhair, P., Thomsen, M., O'Connell, M. J., & Way, M. (2018). Insights into kinesin-1 activation from the crystal structure of KLC2 bound to JIP3. Structure, 26(11), 1486-1498.

Nguyen, T. Q., Aumont-Nicaise, M., Andreani, J., Velours, C., Chenon, M., Vilela, F., ... & Ménétrey, J. (2018). Characterization of the binding mode of JNK-interacting protein 1 (JIP1) to kinesin-light chain 1 (KLC1). Journal of Biological Chemistry, 293(36), 13946-13960.

Pernigo, S., Chegkazi, M. S., Yip, Y. Y., Treacy, C., Glorani, G., Hansen, K., ... & Steiner, R. A. (2018). Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors. Elife, 7, e38362.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-KLC1 Recombinant Antibody (D2T2R)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare