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KLC1

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

Full Name

Kinesin Light Chain 1

Function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Biological Process

Stress granule disassemblyISS:BHF-UCL

Cellular Location

Cell projection, growth cone; Cytoplasm, cytoskeleton

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Anti-KLC1 antibodies

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Rabbit Anti-KLC1 Recombinant Antibody (D2T2R) (CBMAB-CP1307-LY)

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Target: KLC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D2T2R

Application*: WB, IP

Rabbit Anti-KLC1 Recombinant Antibody (CBLY1-103) (CBMAB-K1028-LY)

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Target: KLC1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLY1-103

Application*: WB, IP, P, F, IC/IF

Mouse Anti-KLC1 Recombinant Antibody (CBLY1-104) (CBMAB-K1029-LY)

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Target: KLC1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLY1-104

Application*: WB, IP, IF, E

Human Recombinant KLC1-ALK, Active protein, GST Tag (V2LY-0526-LY5183)

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Target: KLC1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: KLC1 (1-420)-ALK (1058-end)

Tag: GST Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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