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Mouse Anti-KLF12 Antibody (1H9) (CBMAB-0592-YC)

Provided herein are mouse monoclonal antibodies against Human KLF12. The antibody clone 1H9 can be used for immunoassay techniques, such as ELISA and IP.
See all KLF12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H9
Antibody Isotype
IgG2b
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
KLF12
Introduction
KLF12 (kruppel like factor 12) is a member of the Kruppel-like zinc finger protein family. KLF12, binding with a corepressor, CtBP1, can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter.
Entrez Gene ID
11278
UniProt ID
Q9Y4X4
Alternative Names
AP-2rep; AP2REP; HSPC122
Function
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Li, Y., Li, S., Shi, X., Xin, Z., Yang, Y., Zhao, B., ... & Wu, H. (2023). KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner. Cell Death & Disease, 14(5), 313.

Zhang, C. X., Lin, Y. L., Lu, F. F., Yu, L. N., Liu, Y., Zhou, J. D., ... & Cao, G. Y. (2023). Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production. Journal of Biological Chemistry, 299(9).

Pan, X., Zhang, W., Wang, L., Guo, H., Zheng, M., Wu, H., ... & Yang, B. (2023). KLF12 transcriptionally regulates PD‐L1 expression in non‐small cell lung cancer. Molecular Oncology.

Zhang, Q., Wang, J., Qiao, H., Huyan, L., Liu, B., Li, C., ... & Yan, J. (2021). ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell‐like features in cisplatin‐resistant ovarian cancer. Journal of Cellular and Molecular Medicine, 25(9), 4395-4407.

Tang, C., Wang, M., Dai, Y., & Wei, X. (2021). Krüppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2. Gene, 769, 145338.

Lam, V. C., Folkersen, L., Aguilar, O. A., & Lanier, L. L. (2019). KLF12 regulates mouse NK cell proliferation. The Journal of Immunology, 203(4), 981-989.

Zhang, Y., Yan, J., & Pan, X. (2019). miR-141-3p affects apoptosis and migration of endometrial stromal cells by targeting KLF-12. Pflügers Archiv-European Journal of Physiology, 471, 1055-1063.

Ding, L., Ding, Y., Kong, X., Wu, J., Fu, J., Yan, G., & Zhou, H. (2019). Dysregulation of Krüppel-like factor 12 in the development of endometrial cancer. Gynecologic Oncology, 152(1), 177-184.

Huang, C., Sun, H., Wang, Z., Liu, Y., Cheng, X., Liu, J., ... & Jiang, Y. (2018). Increased Krüppel-like factor 12 impairs embryo attachment via downregulation of leukemia inhibitory factor in women with recurrent implantation failure. Cell death discovery, 4(1), 86.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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