Sign in or Register   Sign in or Register
  |  

Mouse Anti-KLF12 Recombinant Antibody (3D2) (CBMAB-K1066-LY)

This product is antibody recognizes KLF12. The antibody 3D2 immunoassay techniques such as: ELISA, WB.
See all KLF12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
KLF12 (NP_009180, 1 a.a. ~ 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MNIHMKRKTI KNINTFENRM LMLDGMPAVR VKTELLESEQ GSPNVHNYPD MEAVPLLLNN VKGEPPEDSL SVDHFQTQTE PVDLSINKAR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KLF12
Introduction
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
11278
UniProt ID
Q9Y4X4
Alternative Names
Kruppel Like Factor 12; KLF12 Zinc Finger Transcriptional Repressor; Transcriptional Repressor AP-2rep; AP-2rep Transcription Factor; AP-2 Repressor; AP2REP; Krueppel-Like Factor 12; AP-2rep; HSPC122;
Function
Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.
Biological Process
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Li, Y., Li, S., Shi, X., Xin, Z., Yang, Y., Zhao, B., ... & Wu, H. (2023). KLF12 promotes the proliferation of breast cancer cells by reducing the transcription of p21 in a p53-dependent and p53-independent manner. Cell Death & Disease, 14(5), 313.

Zhang, C. X., Lin, Y. L., Lu, F. F., Yu, L. N., Liu, Y., Zhou, J. D., ... & Cao, G. Y. (2023). Krüppel-like factor 12 regulates aging ovarian granulosa cell apoptosis by repressing SPHK1 transcription and sphingosine-1-phosphate (S1P) production. Journal of Biological Chemistry, 299(9).

Pan, X., Zhang, W., Wang, L., Guo, H., Zheng, M., Wu, H., ... & Yang, B. (2023). KLF12 transcriptionally regulates PD‐L1 expression in non‐small cell lung cancer. Molecular Oncology.

Zhang, Q., Wang, J., Qiao, H., Huyan, L., Liu, B., Li, C., ... & Yan, J. (2021). ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell‐like features in cisplatin‐resistant ovarian cancer. Journal of Cellular and Molecular Medicine, 25(9), 4395-4407.

Tang, C., Wang, M., Dai, Y., & Wei, X. (2021). Krüppel-like factor 12 suppresses bladder cancer growth through transcriptionally inhibition of enolase 2. Gene, 769, 145338.

Lam, V. C., Folkersen, L., Aguilar, O. A., & Lanier, L. L. (2019). KLF12 regulates mouse NK cell proliferation. The Journal of Immunology, 203(4), 981-989.

Zhang, Y., Yan, J., & Pan, X. (2019). miR-141-3p affects apoptosis and migration of endometrial stromal cells by targeting KLF-12. Pflügers Archiv-European Journal of Physiology, 471, 1055-1063.

Ding, L., Ding, Y., Kong, X., Wu, J., Fu, J., Yan, G., & Zhou, H. (2019). Dysregulation of Krüppel-like factor 12 in the development of endometrial cancer. Gynecologic Oncology, 152(1), 177-184.

Huang, C., Sun, H., Wang, Z., Liu, Y., Cheng, X., Liu, J., ... & Jiang, Y. (2018). Increased Krüppel-like factor 12 impairs embryo attachment via downregulation of leukemia inhibitory factor in women with recurrent implantation failure. Cell death discovery, 4(1), 86.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-KLF12 Recombinant Antibody (3D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare