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Mouse Anti-KLF3 Recombinant Antibody (CBLY1-108) (CBMAB-K1090-LY)

This product is antibody recognizes KLF3. The antibody CBLY1-108 immunoassay techniques such as: WB, IP, IF, ELISA.
See all KLF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLY1-108
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kruppel Like Factor 3
Introduction
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).
Entrez Gene ID
51274
UniProt ID
P57682
Alternative Names
Kruppel Like Factor 3; CACCC-Box-Binding Protein BKLF; Kruppel-Like Factor 3 (Basic); Basic Krueppel-Like Factor; Basic Kruppel-Like Factor; TEF-2;
Function
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity).
Biological Process
Cellular response to peptideIEA:Ensembl
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
PTM
Sumoylated with SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site (By similarity).

Li, Y., Wang, Y., Zou, Q., Li, S., & Zhang, F. (2023). KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway. Laboratory Investigation, 103(6), 100078.

Wang, W., Li, Y., Li, Z., Wang, N., Xiao, F., Gao, H., ... & Wang, S. (2021). Polymorphisms of KLF3 gene coding region and identification of their functionality for abdominal fat in chickens. Veterinary Medicine and Science, 7(3), 792-799.

Knights, A. J., Yang, L., Shah, M., Norton, L. J., Green, G. S., Stout, E. S., ... & Quinlan, K. G. (2020). Krüppel-like factor 3 (KLF3) suppresses NF-κB–driven inflammation in mice. Journal of Biological Chemistry, 295(18), 6080-6091.

Jones, J., Chen, Y., Tiwari, M., Li, J., Ling, J., & Sen, G. L. (2020). KLF3 mediates epidermal differentiation through the epigenomic writer CBP. Iscience, 23(7).

Sun, W., Hu, S., Zu, Y., & Deng, Y. (2019). KLF3 is a crucial regulator of metastasis by controlling STAT3 expression in lung cancer. Molecular carcinogenesis, 58(11), 1933-1945.

Wang, R., Xu, J., Xu, J., Zhu, W., Qiu, T., Li, J., ... & Shu, Y. (2019). MiR‐326/Sp1/KLF3: A novel regulatory axis in lung cancer progression. Cell proliferation, 52(2), e12551.

Guo, H., Raza, S. H. A., Schreurs, N. M., Khan, R., Wei, D., Wang, L. I., ... & Zan, L. (2018). Genetic variants in the promoter region of the KLF3 gene associated with fat deposition in Qinchuan cattle. Gene, 672, 50-55.

Guo, H., Khan, R., Raza, S. H. A., Ning, Y., Wei, D., Wu, S., ... & Zan, L. (2018). KLF15 promotes transcription of KLF3 gene in bovine adipocytes. Gene, 659, 77-83.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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