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Mouse Anti-KLK3 Recombinant Antibody (981) (CBMAB-K1270-LY)

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Basic Information

Host Animal
Mouse
Clone
981
Application
ELISA
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Kallikrein Related Peptidase 3
Introduction
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Entrez Gene ID
354
UniProt ID
P07288
Alternative Names
Kallikrein Related Peptidase 3; Gamma-Seminoprotein; P-30 Antigen; Kallikrein-3; Semenogelase; Seminin; APS; PSA;
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Biological Process
Cellular protein metabolic processTAS:Reactome
Negative regulation of angiogenesis1 PublicationNAS:UniProtKB
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIDA:UniProtKB
ProteolysisManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of systemic arterial blood pressureManual Assertion Based On ExperimentIBA:GO_Central
Zymogen activationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted

Raimondo, S., Gentile, M., Esposito, G., Gentile, T., Ferrara, I., Crescenzo, C., ... & Montano, L. (2021). Could kallikrein-related serine peptidase 3 be an early biomarker of environmental exposure in young women?. International Journal of Environmental Research and Public Health, 18(16), 8833.

Koistinen, H., Künnapuu, J., & Jeltsch, M. (2021). KLK3 in the Regulation of Angiogenesis—Tumorigenic or Not?. International Journal of Molecular Sciences, 22(24), 13545.

Motamedi, R. K., Sarhangi, N., Afshari, M., Sattari, M., Jamaldini, S. H., Samzadeh, M., ... & Hasanzad, M. (2019). Kallikarein‐related peptidase 3 common genetic variant and the risk of prostate cancer. Journal of Cellular Biochemistry, 120(9), 14822-14830.

Ding, W. H., Ren, K. W., Yue, C., Zou, J. G., Zuo, L., Zhang, L. F., ... & Mi, Y. Y. (2018). Association between three genetic variants in kallikrein 3 and prostate cancer risk. Bioscience reports, 38(6), BSR20181151.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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