Mouse Anti-KLK4 Recombinant Antibody (2A4) (CBMAB-K1294-LY)

Name: Mouse Anti-KLK4 Recombinant Antibody (2A4)
SKU: CBMAB-K1294-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2A4

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa159-254 from KLK4 with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kallikrein-related peptidase 4

Introduction

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]

Entrez Gene ID

9622

UniProt ID

Q9Y5K2

Alternative Names

Kallikrein Related Peptidase 4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; Serine Protease 17; Prostase; PRSS17; KLK-L1; EMSP1; PSTS; Kallikrein 4 (Prostase; Enamel Matrix; Prostate);

Function

Has a major role in enamel formation (PubMed:15235027).
Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).

Biological Process

AmelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biomineral tissue developmentIEA:UniProtKB-KW
Extracellular matrix disassemblyManual Assertion Based On ExperimentIBA:GO_Central
Proteolysis1 PublicationNAS:UniProtKB

Cellular Location

Secreted

Involvement in disease

Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1):
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.

PTM

N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.

Fang, Y., Ouyang, Q., Zheng, Z., & Wang, J. (2023). KLK4 affects the biological behavior of oral squamous cell carcinoma through Wnt/β catenin and PI3K/Akt signaling pathways. Tropical Journal of Pharmaceutical Research, 22(2), 233-238.

Gong, W., Zhu, C., Liu, Y., Muckenhuber, A., Bronger, H., Scorilas, A., ... & Dreyer, T. (2021). Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer. American Journal of Translational Research, 13(3), 1594.

Gong, W., Liu, Y., Seidl, C., Dreyer, T., Drecoll, E., Kotzsch, M., ... & Magdolen, V. (2019). Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients. PloS one, 14(2), e0212968.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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