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Mouse Anti-KLK4 Recombinant Antibody (2A4) (CBMAB-K1294-LY)

This product is antibody recognizes KLK4. The antibody 2A4 immunoassay techniques such as: ELISA, WB.
See all KLK4 antibodies
Published Data
Fig.1 KLK4 detection in oral squamous cell carcinomas lines (SCC4 and Cal 27 comparatively) at protein (B; immunofluorescence) levels.
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Fig.2 KLK4 shRNA down-regulated the KLK4 levels in OSCC cells.
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Fig.3 The levels of PCNA in each group were detected by immunofluorescence.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2A4
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa159-254 from KLK4 with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kallikrein-related peptidase 4
Introduction
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]
Entrez Gene ID
9622
UniProt ID
Q9Y5K2
Alternative Names
Kallikrein Related Peptidase 4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; Serine Protease 17; Prostase; PRSS17; KLK-L1; EMSP1; PSTS; Kallikrein 4 (Prostase; Enamel Matrix; Prostate);
Function
Has a major role in enamel formation (PubMed:15235027).
Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
Biological Process
AmelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biomineral tissue developmentIEA:UniProtKB-KW
Extracellular matrix disassemblyManual Assertion Based On ExperimentIBA:GO_Central
Proteolysis1 PublicationNAS:UniProtKB
Cellular Location
Secreted
Involvement in disease
Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1):
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
PTM
N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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