Human Recombinant KLK4 protein, His Tag (V2LY-0526-LY5190)

Name: Human Recombinant KLK4 protein, His Tag
SKU: V2LY-0526-LY5190
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KLK4 protein, His Tag consist of Amino Acid: 31-254 and predicts a molecular mass of 26.89 kDa.

Molecule Mass

26.89 kDa

Sequence

Amino Acid: 31-254

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

kallikrein-related peptidase 4

Function

Has a major role in enamel formation (PubMed:15235027).
Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).

Biological Process

AmelogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biomineral tissue developmentIEA:UniProtKB-KW
Extracellular matrix disassemblyManual Assertion Based On ExperimentIBA:GO_Central
Proteolysis1 PublicationNAS:UniProtKB

Cellular Location

Secreted

Involvement in disease

Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1):
A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.

PTM

N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.

Fang, Y., Ouyang, Q., Zheng, Z., & Wang, J. (2023). KLK4 affects the biological behavior of oral squamous cell carcinoma through Wnt/β catenin and PI3K/Akt signaling pathways. Tropical Journal of Pharmaceutical Research, 22(2), 233-238.

Gong, W., Zhu, C., Liu, Y., Muckenhuber, A., Bronger, H., Scorilas, A., ... & Dreyer, T. (2021). Elevated levels of both microRNA 378 (miR-378) and kallikrein-related peptidase 4 (KLK4) mRNA are associated with an unfavorable prognosis in triple-negative breast cancer. American Journal of Translational Research, 13(3), 1594.

Gong, W., Liu, Y., Seidl, C., Dreyer, T., Drecoll, E., Kotzsch, M., ... & Magdolen, V. (2019). Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients. PloS one, 14(2), e0212968.

Wang, P., Magdolen, V., Seidl, C., Dorn, J., Drecoll, E., Kotzsch, M., ... & Loessner, D. (2018). Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer. British journal of cancer, 119(7), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK4 protein, His Tag-1 (CAT#: V2LY-0526-LY5191)

Related Products

Human Recombinant KLK4 protein, His Tag-1 (CAT#: V2LY-0526-LY5191)

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Rabbit Anti-KLK4 Recombinant Antibody (CBLQK-001) (CAT#: CBMAB-2059CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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