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Mouse Anti-KLK5 Recombinant Antibody (3H3) (CBMAB-K1301-LY)

This product is antibody recognizes KLK5. The antibody 3H3 immunoassay techniques such as: ELISA.
See all KLK5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H3
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa194-294 from human KLK5 (NP_036559) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kallikrein-related peptidase 5
Introduction
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Entrez Gene ID
25818
UniProt ID
Q9Y337
Alternative Names
Kallikrein Related Peptidase 5; Stratum Corneum Tryptic Enzyme; Kallikrein-Like Protein 2; KLK-L2; SCTE; Kallikrein 5;
Function
May be involved in desquamation.
Biological Process
AmelogenesisManual Assertion Based On ExperimentIBA:GO_Central
CornificationTAS:Reactome
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Extracellular matrix disassemblyManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of antibacterial peptide productionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted

Song, Y., Bai, G., Li, X., Zhou, L., Si, Y., Liu, X., ... & Shi, Y. (2023). Bioinformatics analysis of human kallikrein 5 (KLK5) expression in metaplastic triple‐negative breast cancer. Cancer Innovation.

Lenga Ma Bonda, W., Lavergne, M., Vasseur, V., Brisson, L., Roger, S., Legras, A., ... & Reverdiau, P. (2021). Kallikrein‐related peptidase 5 contributes to the remodeling and repair of bronchial epithelium. The FASEB Journal, 35(10), e21838.

Liddle, J., Beneton, V., Benson, M., Bingham, R., Bouillot, A., Boullay, A. B., ... & Hovnanian, A. (2021). A potent and selective kallikrein-5 inhibitor delivers high pharmacological activity in skin from patients with Netherton syndrome. Journal of Investigative Dermatology, 141(9), 2272-2279.

Abuduhadeer, X., Xu, X., Aihesan, K., Yilihamu, M., Zhao, Y., & Zhang, W. (2021). Clinical significance of kallikrein 5 as a novel prognostic biomarker in gastric adenocarcinoma. Journal of Clinical Laboratory Analysis, 35(10), e23958.

Chang, J. S., Kim, N., Kim, J. Y., Do, S. I., Cho, Y., Kim, H. S., & Kim, Y. B. (2020). Kallikrein 5 overexpression is associated with poor prognosis in uterine cervical cancer. Journal of Gynecologic Oncology, 31(6).

Azouz, N. P., Klingler, A. M., Pathre, P., Besse, J. A., Baruch-Morgenstern, N. B., Ballaban, A. Y., ... & Rothenberg, M. E. (2020). Functional role of kallikrein 5 and proteinase-activated receptor 2 in eosinophilic esophagitis. Science translational medicine, 12(545), eaaz7773.

Papachristopoulou, G., Malachias, A., Devetzi, M., Kamouza, E., Scorilas, A., Xynopoulos, D., & Talieri, M. (2019). Uncovering the clinical impact of kallikrein-related peptidase 5 (KLK5) mRNA expression in the colorectal adenoma-carcinoma sequence. Clinical Chemistry and Laboratory Medicine (CCLM), 57(8), 1251-1260.

Gong, W., Liu, Y., Seidl, C., Diamandis, E. P., Kiechle, M., Drecoll, E., ... & Dorn, J. (2019). Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer. BMC cancer, 19, 1-9.

White, G. V., Edgar, E. V., Holmes, D. S., Lewell, X. Q., Liddle, J., Polyakova, O., ... & Hovnanian, A. (2019). Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome. Bioorganic & Medicinal Chemistry Letters, 29(6), 821-825.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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