Mouse Anti-KLK8 Recombinant Antibody (1G8) (CBMAB-K1345-LY)

Name: Mouse Anti-KLK8 Recombinant Antibody (1G8)
SKU: CBMAB-K1345-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1G8

Application

Immunogen

Human recombinant protein fragment corresponding to amino acids 33-260 of human KLK8 (NP_009127) produced in SF9 cell

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Kallikrein Related Peptidase 8

Introduction

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Entrez Gene ID

11202

UniProt ID

O60259

Alternative Names

Kallikrein Related Peptidase 8; Tumor-Associated Differentially Expressed Gene 14 Protein; Serine Protease TADG-14; Serine Protease 19; Ovasin; PRSS19; TADG14; NRPN; NP;

Function

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Biological Process

Cell deathISS:UniProtKB
Keratinocyte proliferationISS:UniProtKB
MemoryISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of myelinationISS:UniProtKB
Neuron projection morphogenesisISS:UniProtKB
Regulation of synapse organizationISS:UniProtKB
Response to woundingISS:UniProtKB
Synapse organizationIEA:Ensembl

Cellular Location

Secreted 1 Publication
Cytoplasm 1 Publication
Shows a cytoplasmic distribution in the keratinocytes.

Schramm, S., Krizanovic, N., Roggenbuck, U., Jöckel, K. H., Herring, A., Keyvani, K., & Jokisch, M. (2023). Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study. Journal of Alzheimer's Disease Reports, (Preprint), 1-11.

Shiosaka, S. (2022). Kallikrein 8: A key sheddase to strengthen and stabilize neural plasticity. Neuroscience & Biobehavioral Reviews, 104774.

Sun, H., Li, J., Wang, Q., Li, F., Zhang, M., Su, Y., ... & Feng, J. (2022). Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced right ventricular hypertrophy by targeting P38 MAPK/P53 signaling pathway. Tissue and Cell, 78, 101874.

Du, J. K., Yu, Q., Liu, Y. J., Du, S. F., Huang, L. Y., Xu, D. H., ... & Zhu, X. Y. (2021). A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics, 11(9), 4207.

Teuber-Hanselmann, S., Rekowski, J., Vogelgsang, J., von Arnim, C., Reetz, K., Stang, A., ... & Keyvani, K. (2020). CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 91(1), 40-48.

Münster, Y., Keyvani, K., & Herring, A. (2020). Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model. Experimental Neurology, 324, 113115.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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