KLK8
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Full Name
Kallikrein Related Peptidase 8
Function
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Biological Process
Cell deathISS:UniProtKB
Keratinocyte proliferationISS:UniProtKB
MemoryISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of myelinationISS:UniProtKB
Neuron projection morphogenesisISS:UniProtKB
Regulation of synapse organizationISS:UniProtKB
Response to woundingISS:UniProtKB
Synapse organizationIEA:Ensembl
Keratinocyte proliferationISS:UniProtKB
MemoryISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of myelinationISS:UniProtKB
Neuron projection morphogenesisISS:UniProtKB
Regulation of synapse organizationISS:UniProtKB
Response to woundingISS:UniProtKB
Synapse organizationIEA:Ensembl
Cellular Location
Secreted 1 Publication
Cytoplasm 1 Publication
Shows a cytoplasmic distribution in the keratinocytes.
Cytoplasm 1 Publication
Shows a cytoplasmic distribution in the keratinocytes.
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Anti-KLK8 antibodies
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CompareTarget: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: UMAB84
Application*: IH
Target: KLK8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: BE
Application*: E, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: AJE
Application*: E
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9H7
Application*: IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 9G374
Application*: E, IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 8F2
Application*: IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8F1
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 6G15
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F4
Application*: IF
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F2
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6D6
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6D5
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5D1
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4E13
Application*: WB, IH, IF
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A5
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G5
Application*: P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G3
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3F3
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C10
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A12
Application*: WB
Target: KLK8
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: 369910
Application*: IP, N
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F11
Application*: E, IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2C6
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2C10
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2A5
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A1
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1H6
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G8
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F9
Application*: IF
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E2
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1D2
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: IF
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-52674
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A10
Application*: IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14G10
Application*: IF, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14E11
Application*: IF, P, WB
Target: KLK8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 140
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13D9
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11C3
Application*: P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10G6
Application*: WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10F9
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10D3
Application*: IF, P, WB
Target: KLK8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: F10
Application*: WB
Target: KLK8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBLY1-125
Application*: WB, IP, P
Target: KLK8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: B12
Application*: E, WB
Target: KLK8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0474
Application*: E
Target: Klk8
Sensitivity: 0.01 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: KLK8
Sensitivity: 0.023 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: KLK8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-260
Tag: His Tag
Target: KLK8
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 33-260
Tag: His Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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