Human KLK8 ELISA Kit (V2LY-0626-LY1203)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.023 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
28.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Kallikrein Related Peptidase 8
Function
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.
Biological Process
Cell deathISS:UniProtKB
Keratinocyte proliferationISS:UniProtKB
MemoryISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of myelinationISS:UniProtKB
Neuron projection morphogenesisISS:UniProtKB
Regulation of synapse organizationISS:UniProtKB
Response to woundingISS:UniProtKB
Synapse organizationIEA:Ensembl
Cellular Location
Secreted 1 Publication
Cytoplasm 1 Publication
Shows a cytoplasmic distribution in the keratinocytes.

Schramm, S., Krizanovic, N., Roggenbuck, U., Jöckel, K. H., Herring, A., Keyvani, K., & Jokisch, M. (2023). Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study. Journal of Alzheimer's Disease Reports, (Preprint), 1-11.

Shiosaka, S. (2022). Kallikrein 8: A key sheddase to strengthen and stabilize neural plasticity. Neuroscience & Biobehavioral Reviews, 104774.

Sun, H., Li, J., Wang, Q., Li, F., Zhang, M., Su, Y., ... & Feng, J. (2022). Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced right ventricular hypertrophy by targeting P38 MAPK/P53 signaling pathway. Tissue and Cell, 78, 101874.

Du, J. K., Yu, Q., Liu, Y. J., Du, S. F., Huang, L. Y., Xu, D. H., ... & Zhu, X. Y. (2021). A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics, 11(9), 4207.

Teuber-Hanselmann, S., Rekowski, J., Vogelgsang, J., von Arnim, C., Reetz, K., Stang, A., ... & Keyvani, K. (2020). CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 91(1), 40-48.

Münster, Y., Keyvani, K., & Herring, A. (2020). Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model. Experimental Neurology, 324, 113115.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK8 protein, His Tag (CAT#: V2LY-0526-LY5128)

Human Recombinant KLK8 protein, His Tag-1 (CAT#: V2LY-0526-LY5129)

Mouse Klk8 ELISA Kit (CAT#: V2LY-0626-LY1545)

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Mouse Anti-KLK8 Recombinant Antibody (1F9) (CAT#: CBMAB-K1344-LY)

Rabbit Anti-KLK8 Recombinant Antibody (CBLY1-125) (CAT#: CBMAB-K1323-LY)

Mouse Anti-KLK8 Recombinant Antibody (9G374) (CAT#: CBMAB-K1377-LY)

Rat Anti-KLK8 Recombinant Antibody (369910) (CAT#: CBMAB-K1355-LY)

Mouse Anti-KLK8 Recombinant Antibody (6G15) (CAT#: CBMAB-K1374-LY)

Mouse Anti-KLK8 Recombinant Antibody (4A5) (CAT#: CBMAB-K1363-LY)

Mouse Anti-KLK8 Recombinant Antibody (3F3) (CAT#: CBMAB-K1359-LY)

Isotype control

For research use only. Not intended for any clinical use.

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