Human Recombinant KLK8 protein, His Tag-1 (V2LY-0526-LY5129)

Name: Human Recombinant KLK8 protein, His Tag-1
SKU: V2LY-0526-LY5129
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KLK8 protein, His Tag consist of Amino Acid: 1-260 and predicts a molecular mass of 26.4 kDa.

Molecule Mass

26.4 kDa

Sequence

Amino Acid: 1-260

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>98% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Kallikrein Related Peptidase 8

Function

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Biological Process

Cell deathISS:UniProtKB
Keratinocyte proliferationISS:UniProtKB
MemoryISS:UniProtKB
Negative regulation of axon regenerationISS:UniProtKB
Negative regulation of myelinationISS:UniProtKB
Neuron projection morphogenesisISS:UniProtKB
Regulation of synapse organizationISS:UniProtKB
Response to woundingISS:UniProtKB
Synapse organizationIEA:Ensembl

Cellular Location

Secreted 1 Publication
Cytoplasm 1 Publication
Shows a cytoplasmic distribution in the keratinocytes.

Schramm, S., Krizanovic, N., Roggenbuck, U., Jöckel, K. H., Herring, A., Keyvani, K., & Jokisch, M. (2023). Blood Kallikrein-8 and Non-Amnestic Mild Cognitive Impairment: An Exploratory Study. Journal of Alzheimer's Disease Reports, (Preprint), 1-11.

Shiosaka, S. (2022). Kallikrein 8: A key sheddase to strengthen and stabilize neural plasticity. Neuroscience & Biobehavioral Reviews, 104774.

Sun, H., Li, J., Wang, Q., Li, F., Zhang, M., Su, Y., ... & Feng, J. (2022). Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced right ventricular hypertrophy by targeting P38 MAPK/P53 signaling pathway. Tissue and Cell, 78, 101874.

Du, J. K., Yu, Q., Liu, Y. J., Du, S. F., Huang, L. Y., Xu, D. H., ... & Zhu, X. Y. (2021). A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis. Theranostics, 11(9), 4207.

Teuber-Hanselmann, S., Rekowski, J., Vogelgsang, J., von Arnim, C., Reetz, K., Stang, A., ... & Keyvani, K. (2020). CSF and blood Kallikrein-8: a promising early biomarker for Alzheimer’s disease. Journal of Neurology, Neurosurgery & Psychiatry, 91(1), 40-48.

Münster, Y., Keyvani, K., & Herring, A. (2020). Inhibition of excessive kallikrein-8 improves neuroplasticity in Alzheimer's disease mouse model. Experimental Neurology, 324, 113115.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant KLK8 protein, His Tag (CAT#: V2LY-0526-LY5128)

Human KLK8 ELISA Kit (CAT#: V2LY-0626-LY1203)

Mouse Klk8 ELISA Kit (CAT#: V2LY-0626-LY1545)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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