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Mouse Anti-KMO Recombinant Antibody (A778) (CBMAB-AP11225LY)

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Basic Information

Host Animal
Mouse
Clone
A778
Application
ELISA, IF, IHC, WB
Immunogen
Fusion protein of Kynurenine 3 monooxygenase
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Kynurenine 3-Monooxygenase
Introduction
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease. [provided by RefSeq, Oct 2011]
Entrez Gene ID
Human8564
Mouse98256
Rat59113
UniProt ID
HumanO15229
MouseQ91WN4
RatO88867
Alternative Names
Kynurenine 3-Monooxygenase; Kynurenine 3-Hydroxylase; EC 1.14.13.9; Kynurenine 3-Monooxygenase (Kynurenine 3-Hydroxylase); DJ317G22.1;
Function
E-AB-27228
Biological Process
de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
AgingIEA:Ensembl
Anthranilate metabolic processIEA:UniProtKB-UniRule
Cellular response to interleukin-1IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Kynurenic acid biosynthetic processIEA:Ensembl
Kynurenine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine metabolic processIEA:Ensembl
NAD metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glutamate secretion, neurotransmissionIEA:Ensembl
Positive regulation of neuron deathIEA:Ensembl
Quinolinate biosynthetic processIEA:UniProtKB-UniRule
Response to salt stressManual Assertion Based On ExperimentIDA:UniProtKB
Tryptophan catabolic processTAS:Reactome
Cellular Location
Mitochondrion outer membrane

Sathyasaikumar, K. V., Pérez de la Cruz, V., Pineda, B., Vázquez Cervantes, G. I., Ramírez Ortega, D., Donley, D. W., ... & Schwarcz, R. (2022). Cellular localization of kynurenine 3-monooxygenase in the brain: Challenging the dogma. Antioxidants, 11(2), 315.

Chen, Y., Zhang, J., Yang, Y., Xiang, K., Li, H., Sun, D., & Chen, L. (2022). Kynurenine‐3‐monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of Cellular Physiology, 237(12), 4339-4355.

Hughes, T. D., Güner, O. F., Iradukunda, E. C., Phillips, R. S., & Bowen, J. P. (2022). The kynurenine pathway and kynurenine 3-monooxygenase inhibitors. Molecules, 27(1), 273.

Zhao, J., Chen, J., Wang, C., Liu, Y., Li, M., Li, Y., ... & Sun, C. (2022). Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/IRF3-mediated IFN-β production. PLoS Pathogens, 18(3), e1010366.

Liu, C. Y., Huang, T. T., Chen, J. L., Chu, P. Y., Lee, C. H., Lee, H. C., ... & Teng, H. W. (2021). Significance of kynurenine 3-monooxygenase expression in colorectal cancer. Frontiers in Oncology, 11, 620361.

Bondulich, M. K., Fan, Y., Song, Y., Giorgini, F., & Bates, G. P. (2021). Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease. Scientific Reports, 11(1), 5484.

Lu, Y., Shao, M., & Wu, T. (2020). Kynurenine‐3‐monooxygenase: A new direction for the treatment in different diseases. Food Science & Nutrition, 8(2), 711-719.

Huang, T. T., Tseng, L. M., Chen, J. L., Chu, P. Y., Lee, C. H., Huang, C. T., ... & Liu, C. Y. (2020). Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression. EBioMedicine, 54.

Zheng, X., Zhang, A., Binnie, M., McGuire, K., Webster, S. P., Hughes, J., ... & Mole, D. J. (2019). Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury. Experimental & Molecular Medicine, 51(2), 1-14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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