Rat Kmo ELISA Kit (V2LY-0626-LY2405)

See all Kmo antibodies
Go to compare Compare Online Inquiry
Tested Data
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0044 ng/mL
Detection Range
0.01-2 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Rat
Assay Type
Sandwich
Reactivity
Rat
Assay Time
1.5 h
Molecule Mass
54.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Kynurenine 3-Monooxygenase
Function
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) (PubMed:29429898, PubMed:23575632, PubMed:26752518, PubMed:28604669, PubMed:29208702).
Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable)
Biological Process
de novo' NAD biosynthetic process from tryptophanIEA:UniProtKB-UniRule
AgingIEA:Ensembl
Anthranilate metabolic processIEA:UniProtKB-UniRule
Cellular response to interleukin-1IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Kynurenic acid biosynthetic processIEA:Ensembl
Kynurenine metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
L-kynurenine metabolic processIEA:Ensembl
NAD metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of glutamate secretion, neurotransmissionIEA:Ensembl
Positive regulation of neuron deathIEA:Ensembl
Quinolinate biosynthetic processIEA:UniProtKB-UniRule
Response to salt stressManual Assertion Based On ExperimentIDA:UniProtKB
Tryptophan catabolic processTAS:Reactome
Cellular Location
Mitochondrion outer membrane

Sathyasaikumar, K. V., Pérez de la Cruz, V., Pineda, B., Vázquez Cervantes, G. I., Ramírez Ortega, D., Donley, D. W., ... & Schwarcz, R. (2022). Cellular localization of kynurenine 3-monooxygenase in the brain: Challenging the dogma. Antioxidants, 11(2), 315.

Chen, Y., Zhang, J., Yang, Y., Xiang, K., Li, H., Sun, D., & Chen, L. (2022). Kynurenine‐3‐monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of Cellular Physiology, 237(12), 4339-4355.

Hughes, T. D., Güner, O. F., Iradukunda, E. C., Phillips, R. S., & Bowen, J. P. (2022). The kynurenine pathway and kynurenine 3-monooxygenase inhibitors. Molecules, 27(1), 273.

Zhao, J., Chen, J., Wang, C., Liu, Y., Li, M., Li, Y., ... & Sun, C. (2022). Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/IRF3-mediated IFN-β production. PLoS Pathogens, 18(3), e1010366.

Liu, C. Y., Huang, T. T., Chen, J. L., Chu, P. Y., Lee, C. H., Lee, H. C., ... & Teng, H. W. (2021). Significance of kynurenine 3-monooxygenase expression in colorectal cancer. Frontiers in Oncology, 11, 620361.

Bondulich, M. K., Fan, Y., Song, Y., Giorgini, F., & Bates, G. P. (2021). Ablation of kynurenine 3-monooxygenase rescues plasma inflammatory cytokine levels in the R6/2 mouse model of Huntington’s disease. Scientific Reports, 11(1), 5484.

Lu, Y., Shao, M., & Wu, T. (2020). Kynurenine‐3‐monooxygenase: A new direction for the treatment in different diseases. Food Science & Nutrition, 8(2), 711-719.

Huang, T. T., Tseng, L. M., Chen, J. L., Chu, P. Y., Lee, C. H., Huang, C. T., ... & Liu, C. Y. (2020). Kynurenine 3-monooxygenase upregulates pluripotent genes through β-catenin and promotes triple-negative breast cancer progression. EBioMedicine, 54.

Zheng, X., Zhang, A., Binnie, M., McGuire, K., Webster, S. P., Hughes, J., ... & Mole, D. J. (2019). Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury. Experimental & Molecular Medicine, 51(2), 1-14.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Kmo ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-KMO Recombinant Antibody (2D2F2) (CAT#: CBMAB-K1425-LY)

Mouse Anti-KMO Recombinant Antibody (A778) (CAT#: CBMAB-AP11225LY)

Mouse Anti-KMO Recombinant Antibody (CF257) (CAT#: CBMAB-FT240LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.