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Rat Anti-KREMEN1 Recombinant Antibody (14L675) (CBMAB-K1526-LY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
14L675
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to extracellular domain of mouse Kremen-1
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kringle containing transmembrane protein 1
Introduction
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
84035
UniProt ID
Q99N43
Alternative Names
AV002070; Kremen; Krm1
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Biological Process
Apoptotic processISS:UniProtKB
Cell communicationManual Assertion Based On ExperimentTAS:UniProtKB
Limb developmentISS:UniProtKB
Negative regulation of axon regenerationIEA:Ensembl
Negative regulation of canonical Wnt signaling pathwayISS:UniProtKB
Negative regulation of ossificationIEA:Ensembl
Regulation of canonical Wnt signaling pathway1 PublicationNAS:BHF-UCL
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cell membrane
Involvement in disease
Ectodermal dysplasia 13, hair/tooth type (ECTD13):
A form of ectodermal dysplasia, a disorder due to abnormal development of two or more ectodermal structures. ECTD13 is an autosomal recessive form characterized by severe oligodontia accompanied by anomalies of hair and skin.
Topology
Extracellular: 21-392
Helical: 393-413
Cytoplasmic: 414-473
More Infomation

Li, X., Liu, Z., Yan, X., Tian, Y., Liu, K., Zhao, Y., ... & Zhang, C. (2023). VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice. Plos Pathogens, 19(10), e1011662.

Gu, Y., Cao, J., Zhang, X., Gao, H., Wang, Y., Wang, J., ... & Lu, Z. (2022). Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2. Cell research, 32(1), 24-37.

Hoffmann, M., & Pöhlmann, S. (2022). Novel sars-Cov-2 receptors: Asgr1 and Kremen1. Cell Research, 32(1), 1-2.

Xu, Y., Nowrangi, D., Liang, H., Wang, T., Yu, L., Lu, T., ... & Tang, J. (2020). DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage. Journal of Neuroinflammation, 17(1), 1-14.

Zhao, Y., Zhou, D., Ni, T., Karia, D., Kotecha, A., Wang, X., ... & Stuart, D. I. (2020). Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10. Nature communications, 11(1), 38.

Sumia, I., Pierani, A., & Causeret, F. (2019). Kremen1-induced cell death is regulated by homo-and heterodimerization. Cell death discovery, 5(1), 91.

Wang, H., Lu, B., & Chen, J. (2019). Knockdown of lncRNA SNHG1 attenuated Aβ25-35-inudced neuronal injury via regulating KREMEN1 by acting as a ceRNA of miR-137 in neuronal cells. Biochemical and biophysical research communications, 518(3), 438-444.

Staring, J., van den Hengel, L. G., Raaben, M., Blomen, V. A., Carette, J. E., & Brummelkamp, T. R. (2018). KREMEN1 is a host entry receptor for a major group of enteroviruses. Cell Host & Microbe, 23(5), 636-643.

Ross, S. P., Baker, K. E., Fisher, A., Hoff, L., Pak, E. S., & Murashov, A. K. (2018). miRNA-431 prevents amyloid-β-induced synapse loss in neuronal cell culture model of Alzheimer's disease by silencing kremen1. Frontiers in cellular neuroscience, 12, 87.

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For research use only. Not intended for any clinical use.

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