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Mouse Anti-KRT16 Recombinant Antibody (5B1) (CBMAB-AP2852LY)


See all KRT16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B1
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Full length protein from eukaryotic expression system.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol, 0.5% BSA
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratin 16
Introduction
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3868
UniProt ID
P08779
Alternative Names
Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin 16, Type I; KRT16A; K16; Keratin, Type I Cytoskeletal 16; Cytokeratin 16; Cytokeratin-16;
Function
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organization1 PublicationNAS:UniProtKB
Establishment of skin barrierISS:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseISS:UniProtKB
Innate immune responseISS:UniProtKB
Intermediate filament cytoskeleton organizationIEA:Ensembl
KeratinizationISS:UniProtKB
Keratinocyte differentiationISS:UniProtKB
Keratinocyte migrationISS:UniProtKB
Morphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoskeleton
Cytosol
Extracellular exosome
Intermediate filament
Nucleus
Involvement in disease
Pachyonychia congenita 1 (PC1):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1):
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Lu, Z., Peng, H., Li, R., Xu, X., & Peng, J. (2022). BarH-like homeobox 2 represses the transcription of keratin 16 and affects Ras signaling pathway to suppress nasopharyngeal carcinoma progression. Bioengineered, 13(2), 3122-3136.

Elazezy, M., Schwentesius, S., Stegat, L., Wikman, H., Werner, S., Mansour, W. Y., ... & Joosse, S. A. (2021). Emerging insights into keratin 16 expression during metastatic progression of breast cancer. Cancers, 13(15), 3869.

Zhang, X., Yin, M., & Zhang, L. J. (2019). Keratin 6, 16 and 17—critical barrier alarmin molecules in skin wounds and psoriasis. Cells, 8(8), 807.

Huang, W. C., Jang, T. H., Tung, S. L., Yen, T. C., Chan, S. H., & Wang, L. H. (2019). A novel miR-365-3p/EHF/keratin 16 axis promotes oral squamous cell carcinoma metastasis, cancer stemness and drug resistance via enhancing β5-integrin/c-met signaling pathway. Journal of Experimental & Clinical Cancer Research, 38, 1-17.

Zieman, A. G. (2018). A role for keratin 16 in the regulation of epithelial differentiation and homeostasis in glabrous epidermis (Doctoral dissertation, Johns Hopkins University).

Zieman, A., & Coulombe, P. A. (2018). The keratin 16 null phenotype is modestly impacted by genetic strain background in mice. Experimental dermatology, 27(6), 672-674.

Zhang, J., Li, X., Chen, H., Lu, Y., Li, L., Han, L., & Lu, C. (2018). Gallic acid inhibits the expression of keratin 16 and keratin 17 through Nrf2 in psoriasis-like skin disease. International Immunopharmacology, 65, 84-95.

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For research use only. Not intended for any clinical use.

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