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KRT16

The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq, Jul 2008]
Full Name
Keratin 16
Function
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organization1 PublicationNAS:UniProtKB
Establishment of skin barrierISS:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseISS:UniProtKB
Innate immune responseISS:UniProtKB
Intermediate filament cytoskeleton organizationIEA:Ensembl
KeratinizationISS:UniProtKB
Keratinocyte differentiationISS:UniProtKB
Keratinocyte migrationISS:UniProtKB
Morphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoskeleton
Cytosol
Extracellular exosome
Intermediate filament
Nucleus
Involvement in disease
Pachyonychia congenita 1 (PC1):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1):
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.

Anti-KRT16 antibodies

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Mouse Anti-KRT16 Recombinant Antibody (0.N.361) (CBMAB-K1639-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.361
Application*: IF, IH

Mouse Anti-KRT16 Recombinant Antibody (13j59) (CBMAB-K1640-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j59
Application*: E, IC, IH, WB

Mouse Anti-KRT16 Recombinant Antibody (1A9) (CBMAB-K1641-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: WB

Mouse Anti-KRT16 Recombinant Antibody (1G1) (CBMAB-K1642-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G1
Application*: IH, WB

Mouse Anti-KRT16 Recombinant Antibody (1G5) (CBMAB-K1643-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G5
Application*: P, WB

Mouse Anti-KRT16 Recombinant Antibody (2E6) (CBMAB-K1644-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E6
Application*: IH, WB

Mouse Anti-KRT16 Recombinant Antibody (2F10) (CBMAB-K1645-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2F10
Application*: WB

Mouse Anti-KRT16 Recombinant Antibody (2H8) (CBMAB-K1647-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H8
Application*: IH

Mouse Anti-KRT16 Recombinant Antibody (6A11) (CBMAB-K1648-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A11
Application*: IH, WB

Mouse Anti-KRT16 Recombinant Antibody (6A401) (CBMAB-K1649-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A401
Application*: IH

Mouse Anti-KRT16 Recombinant Antibody (7A4) (CBMAB-K1651-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A4
Application*: P, WB

Mouse Anti-KRT16 Recombinant Antibody (LL025) (CBMAB-K1652-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LL025
Application*: WB, IHC, IF

Rabbit Anti-KRT16 Recombinant Antibody (R20-S) (CBMAB-K1653-LY)

Datasheet SDS
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: R20-S
Application*: P, C

Rabbit Anti-KRT16 Recombinant Antibody (CBWJC-2278) (CBMAB-C3145WJ)

Datasheet SDS
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2278
Application*: WB, IP, P, IC, F

Mouse Anti-KRT16 Recombinant Antibody (6F6) (CBMAB-EN852-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6F6
Application*: IHC: 1:200

Mouse Anti-KRT16 Recombinant Antibody (A794) (CBMAB-AP4152LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A794
Application*: ELISA, IHC

Mouse Anti-KRT16 Recombinant Antibody (CBYY-C2975) (CBMAB-C4418-YY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C2975
Application*: IH

Mouse Anti-KRT16 Recombinant Antibody (3G121) (CBMAB-C3795-CN)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G121
Application*: IH

Mouse Anti-KRT16 Recombinant Antibody (Ks1-8) (CBMAB-C3797-CN)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Ks1-8
Application*: IH, WB

Mouse Anti-KRT16 Recombinant Antibody (CBCNC-627) (CBMAB-C3800-CN)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-627
Application*: E, P, IF

Rabbit Anti-KRT16 Recombinant Antibody (CBCNC-628) (CBMAB-C3801-CN)

Datasheet SDS
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-628
Application*: WB, P, IF, FC

Mouse Anti-KRT16 Recombinant Antibody (SPM264) (CBMAB-C11947-LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM264
Application*: P

Mouse Anti-KRT16 Recombinant Antibody (CB118A) (CBMAB-CA118LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB118A
Application*: ELISA, IHC

Mouse Anti-KRT16 Recombinant Antibody (CB368A) (CBMAB-CA368LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB368A
Application*: ELISA, IHC

Mouse Anti-KRT16 Recombinant Antibody (CAP917) (CBMAB-AP2850LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP917
Application*: IHC

Mouse Anti-KRT16 Recombinant Antibody (5B1) (CBMAB-AP2852LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5B1
Application*: IHC

Mouse Anti-KRT16 Recombinant Antibody (A792) (CBMAB-AP4085LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A792
Application*: ICC, IHC, IP, WB

Mouse Anti-KRT16 Recombinant Antibody (A793) (CBMAB-AP4126LY)

Datasheet SDS
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A793
Application*: IF, IHC, IP, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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