KRT16
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Full Name
Keratin 16
Alternative Names
Keratin 16; Focal Non-Epidermolytic Palmoplantar Keratoderma; Keratin 16, Type I; KRT16A; K16; Keratin, Type I Cytoskeletal 16; Cytokeratin 16; Cytokeratin-16;
Function
Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Biological Process
AgingManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organization1 PublicationNAS:UniProtKB
Establishment of skin barrierISS:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseISS:UniProtKB
Innate immune responseISS:UniProtKB
Intermediate filament cytoskeleton organizationIEA:Ensembl
KeratinizationISS:UniProtKB
Keratinocyte differentiationISS:UniProtKB
Keratinocyte migrationISS:UniProtKB
Morphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cytoskeleton organization1 PublicationNAS:UniProtKB
Establishment of skin barrierISS:UniProtKB
Hair cycleManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory responseISS:UniProtKB
Innate immune responseISS:UniProtKB
Intermediate filament cytoskeleton organizationIEA:Ensembl
KeratinizationISS:UniProtKB
Keratinocyte differentiationISS:UniProtKB
Keratinocyte migrationISS:UniProtKB
Morphogenesis of an epitheliumISS:UniProtKB
Negative regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoskeleton
Cytosol
Extracellular exosome
Intermediate filament
Nucleus
Cytosol
Extracellular exosome
Intermediate filament
Nucleus
Involvement in disease
Pachyonychia congenita 1 (PC1):
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1):
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
An autosomal dominant ectodermal dysplasia characterized by hypertrophic nail dystrophy resulting in onchyogryposis (thickening and increase in curvature of the nail), palmoplantar keratoderma, follicular hyperkeratosis, and oral leukokeratosis. Hyperhidrosis of the hands and feet is usually present.
Keratoderma, palmoplantar, non-epidermolytic, focal 1 (FNEPPK1):
A dermatological disorder characterized by non-epidermolytic palmoplantar keratoderma limited to the pressure points on the balls of the feet, with later mild involvement on the palms. Oral, genital and follicular keratotic lesions are often present.
KRT16 and KRT17 are coexpressed only in pathological situations such as metaplasias and carcinomas of the uterine cervix and in psoriasis vulgaris.
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Anti-KRT16 antibodies
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CompareTarget: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: A794
Application*: ELISA, IHC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A793
Application*: IF, IHC, IP, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A792
Application*: ICC, IHC, IP, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5B1
Application*: IHC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP917
Application*: IHC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB368A
Application*: ELISA, IHC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB118A
Application*: ELISA, IHC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SPM264
Application*: P
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNC-628
Application*: WB, P, IF, FC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-627
Application*: E, P, IF
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Ks1-8
Application*: IH, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3G121
Application*: IH
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2278
Application*: WB, IP, P, IC, F
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C2975
Application*: IH
Target: KRT16
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: R20-S
Application*: P, C
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LL025
Application*: WB, IHC, IF
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7A4
Application*: P, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A401
Application*: IH
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A11
Application*: IH, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2H8
Application*: IH
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2F10
Application*: WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E6
Application*: IH, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G5
Application*: P, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G1
Application*: IH, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A9
Application*: WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 13j59
Application*: E, IC, IH, WB
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.361
Application*: IF, IH
Target: KRT16
Sensitivity: 0.023 ng/mL
Detection Range: 0.05-9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 19D5
Application*: E, IH
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 5C1
Application*: E, IH
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT343
Application*: P, IF, IC
Target: KRT16
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC117
Application*: P, IF
Target: KRT16
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 6F6
Application*: IHC: 1:200
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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