Mouse Anti-KRT20 Recombinant Antibody (CBWJC-4043) (CBMAB-C5370WJ)

Name: Mouse Anti-KRT20 Recombinant Antibody (CBWJC-4043)
SKU: CBMAB-C5370WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJC-4043

Application

IHC-Fr, ICC, FC, IHC-P

Specificity

Human, Pig, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Keratin 20

Introduction

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	54474
Rat	286912
Pig	100520330

UniProt ID

Human	P35900
Rat	P25030
Pig	Q29218

Alternative Names

Keratin 20; Keratin 20, Type I; Protein IT; CK-20; K20; Keratin, Type I Cytoskeletal 20; Cytokeratin 20;

Function

Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).

Biological Process

Apoptotic processIEA:UniProtKB-KW
Cellular response to starvationIEA:Ensembl
Intermediate filament organizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein secretionIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Hyperphosphorylation at Ser-13 ^oCcurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity).
Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228.

Lupsa, N., Szegedi, Á., Gézsi, A., Vuncs, Z., Masszi, T., Mikala, G., ... & Pós, Z. (2022). Decreased plasma level of cytokeratin 20 (KRT20) is indicative of the emergence and severity of acute GvHD irrespective to the type of organ involvement. Biomedicines, 10(3), 519.

Jütte, H., Reike, M., Wirtz, R. M., Kriegmair, M., Erben, P., Tully, K., ... & Roghmann, F. (2021). Krt20, krt5, esr1 and erbb2 expression can predict pathologic outcome in patients undergoing neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer. Journal of personalized medicine, 11(6), 473.

Hung, C. S., Wang, Y. C., Guo, J. W., Yang, R. N., Lee, C. L., Shen, M. H., ... & Liu, C. Y. (2020). Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer. Molecular Medicine Reports, 21(2), 659-666.

Eckstein, M., Wirtz, R. M., Gross-Weege, M., Breyer, J., Otto, W., Stoehr, R., ... & Erben, P. (2018). mRNA-expression of KRT5 and KRT20 defines distinct prognostic subgroups of muscle-invasive urothelial bladder cancer correlating with histological variants. International journal of molecular sciences, 19(11), 3396.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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